ArticleNature communications2021
Directed nickel-catalyzed regio- and diastereoselective arylamination of unactivated alkenes.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Nickel-Catalyzed Three-Component Difluoroalkylation-Amination for the Direct Access to Anti-Inflammatory β-Difluoroalkyl Amines.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Catalytic Functionalization of Unactivated π-Bonds Enabled by Bidentate Directing Auxiliaries.Angewandte Chemie (International ed. in English) · 2026Review
- Cobalt-catalyzed alkyne silylamidation unlocksNational science review · 2026Article
- Stereodivergent construction of non-adjacent stereocentres via migratory functionalization of alkenes.Nature chemistry · 2026Article
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- Article
- Noncovalent interaction-driven regio- and enantioselective hydroalkynylation of unactivated alkenes to access remote chiral nitriles.Science advances · 2025Article
- Light-driven radical copper-catalyzed allylic amination via allylic copper intermediates.Nature communications · 2025Article
- Ni-Catalyzed Distal-SelectiveJACS Au · 2025Article
- Palladium-Catalyzed Dual CspAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Three-component dicarbofunctionalization of allylaminesChemical science · 2024Article
- A Catalytic Three-Component Aminofluorination of Unactivated Alkenes with Electron-Rich Amino Sources.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Photoinduced Copper-Catalyzed Late-Stage Azidoarylation of Alkenes via Arylthianthrenium Salts.Journal of the American Chemical Society · 2023Article
- Divergent regioselective Heck-type reaction of unactivated alkenes and N-fluoro-sulfonamides.Nature communications · 2022Article
- Picolinamides and Iodoalkynes Enable Palladium-Catalyzed syn-Aminoalkynylation of Di- and Trisubstituted Alkenes to Give Pyrrolidines.Angewandte Chemie (International ed. in English) · 2022Article
- Directed, nickel-catalyzed 1,2-alkylsulfenylation of alkenyl carbonyl compounds.Chemical science · 2022Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few methods have been reported for intermolecular arylamination of alkenes, which could provide direct access to important arylethylamine scaffolds. Herein, we report an intermolecular syn-1,2-arylamination of unactivated alkenes with arylboronic acids and O-benzoylhydroxylamine electrophiles with Ni(II) catalyst. The cleavable bidentate picolinamide directing group facilitates formation of stabilized 4-, 5- or 6-membered nickelacycles and enables the difunctionalization of diverse alkenyl amines with high levels of regio-, chemo- and diastereocontrol. This general and practical protocol is compatible with broad substrate scope and high functional group tolerance. The utility of this method is further demonstrated by the site-selective modification of pharmaceutical agents.
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Registered trials
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