Evidence map›Paper›PMID 34725343›Full record

ArticleNPJ genomic medicine2021

Underrepresented patient views and perceptions of personalized medication treatment through pharmacogenomics.

Loren Saulsberry, Keith Danahey, Brittany A Borden, Elizabeth Lipschultz, Maimouna Traore, Mark J Ratain, David O Meltzer, Peter H O'Donnell

Open access · goldAbstract read
In one paragraph

Article in NPJ genomic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Loren SaulsberryDepartment of Public Health Sciences, The University of Chicago, Chicago, IL, USA. lsaulsberry@uchicago.edu.ORCID http://orcid.org/0000-0003-0325-2329
Keith DanaheyCenter for Personalized Therapeutics, The University of Chicago, Chicago, IL, USA.
Brittany A BordenCenter for Personalized Therapeutics, The University of Chicago, Chicago, IL, USA.
Elizabeth LipschultzCenter for Personalized Therapeutics, The University of Chicago, Chicago, IL, USA.
Maimouna TraoreCenter for Personalized Therapeutics, The University of Chicago, Chicago, IL, USA.
Mark J RatainCenter for Personalized Therapeutics, The University of Chicago, Chicago, IL, USA.
David O MeltzerSection of Hospital Medicine, Department of Medicine, The University of Chicago, Chicago, IL, USA.
Peter H O'DonnellCenter for Personalized Therapeutics, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2650-0049
University of Chicago · USChicago Department of Public Health · US

Funding

Health Equity and Risk Communication in PharmacogenomicsK08HG011505 · NHGRI · UNIVERSITY OF CHICAGO · PI SAULSBERRY, LOREN · 2020 to 2024
$836k
The 1200 Patients Project: Studying Clinical Implementation of PharmacogenomicsK23GM100288 · NIGMS · UNIVERSITY OF CHICAGO · PI O'DONNELL, PETER HUGH · 2013 to 2016
$751k
NHGRI NIH HHS K08 HG011505NIGMS NIH HHS K23 GM100288UChicago | Bucksbaum Institute for Clinical Excellence (Bucksbaum Institute) Bucksbaum Institute Associate Faculty Scholar Pilot GrantU.S. Department of Health & Human Services | National Institutes of Health (NIH) K23 GM100288-01A1U.S. Department of Health & Human Services | National Institutes of Health (NIH) NIH 2T35D062719-26
6 · The paper itself

Abstract

Within an institutional pharmacogenomics implementation program, we surveyed 463 outpatients completing preemptive pharmacogenomic testing whose genetic results were available to providers for guiding medication treatment. We compared views and experiences from self-reported White and Black patients, including education level as a covariate across analyses. Black patients were less confident about whether their providers made personalized treatment decisions, and overwhelmingly wanted a greater role for their genetic information in clinical care. Both groups similarly reported that providers asked their opinions regarding medication changes, but White patients were more likely (59% vs. 49%, P = 0.005) to discuss the impact of personal/genetic makeup on medication response with providers, and Black patients reported initiating such discussions much less frequently (4% vs. 15%, P = 0.037). Opportunities exist for enhanced communication with underrepresented patients around personalized care. Tailored communication strategies and development of support tools employed in diverse healthcare settings may facilitate pharmacogenomically guided medication treatment that equitably benefits minority patient populations.

Identifiers

PMID34725343
PMCPMC8560901
OpenAlexW3208258215

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.