Evidence map›Paper›PMID 34725213›Full record

ArticleJournal for immunotherapy of cancer2021

Synergy between

Yu-Chao Zhu, Hany M Elsheikha, Jian-Hua Wang, Shuai Fang, Jun-Jun He, Xing-Quan Zhu, Jia Chen

Open access · goldAbstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pathogens (Basel, Switzerland) · 2026
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Molecular therapy. Oncology · 2025
    Article
  9. Article
  10. Article
  11. The anticancer mechanisms ofCancer biology & therapy · 2024
    Article
  12. Parasites revive hope for cancer therapy.European journal of medical research · 2024
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Protozoan-Derived Cytokine-Transgenic Macrophages Reverse Hepatic Fibrosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Yu-Chao ZhuDepartment of Radiology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang, China.ORCID 0000-0002-2596-8590
Hany M ElsheikhaFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, UK xingquanzhu1@hotmail.com chenjia@nbu.edu.cn hany.elsheikha@nottingham.ac.uk.
Jian-Hua WangDepartment of Radiology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang, China.
Shuai FangDepartment of Radiology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang, China.
Jun-Jun HeState Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Xing-Quan ZhuCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, China xingquanzhu1@hotmail.com chenjia@nbu.edu.cn hany.elsheikha@nottingham.ac.uk.
Jia ChenDepartment of Radiology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang, China xingquanzhu1@hotmail.com chenjia@nbu.edu.cn hany.elsheikha@nottingham.ac.uk.
Ningbo University · CNLanzhou Veterinary Research Institute · CNShanxi Agricultural University · CNUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, we hypothesize that the ability of the protozoan

methodsThe effects of administration of

resultsTreatment with

conclusionThe results from these models indicate that intratumoral injection of Δ

Indexed as

AnimalsCell Line, TumorDrug SynergismFemaleHumansImmune Checkpoint InhibitorsImmunotherapyMiceMice, KnockoutToxoplasmaImmune Checkpoint Inhibitorsantineoplastic protocolscombined modality therapyimmunotherapymelanomaprogrammed cell death 1 receptor

Identifiers

PMID34725213
PMCPMC8562526
OpenAlexW3211226529

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.