Evidence map›Paper›PMID 34725189›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Interaural Place-of-Stimulation Mismatch Estimates Using CT Scans and Binaural Perception, But Not Pitch, Are Consistent in Cochlear-Implant Users.

Joshua G W Bernstein, Kenneth K Jensen, Olga A Stakhovskaya, Jack H Noble, Michael Hoa, H Jeffery Kim, Robert Shih, Elizabeth Kolberg, Miranda Cleary, Matthew J Goupell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Anatomy-based fitting improves speech perception in noise for cochlear implant recipients with single-sided deafness.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  5. Binaural fusion: Complexities in definition and measurement.The Journal of the Acoustical Society of America · 2024
    Review
  6. [Research status and progress of bilateral cochlear implantation].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Review
  7. Matching the pitch perception of the cochlear implanted ear with the contralateral ear in patients with single-sided deafness: a novel approach.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
  8. Review
  9. Effect of interaural electrode insertion depth difference and independent band selection on sentence recognition in noise and spatial release from masking in simulated bilateral cochlear implant listening.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joshua G W BernsteinNational Military Audiology and Speech Pathology Center, Walter Reed National Military Medical Center, Bethesda, Maryland 20889 joshua.g.bernstein.civ@mail.mil.
Kenneth K JensenNational Military Audiology and Speech Pathology Center, Walter Reed National Military Medical Center, Bethesda, Maryland 20889.
Olga A StakhovskayaDepartment of Hearing and Speech Sciences, University of Maryland, College Park, Maryland 20742.
Jack H NobleDepartment of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, Tennessee 37232.
Michael HoaDepartment of Otolaryngology Head and Neck Surgery, Georgetown University Medical Center, Washington, DC 20057.
H Jeffery KimDepartment of Otolaryngology Head and Neck Surgery, Georgetown University Medical Center, Washington, DC 20057.
Robert ShihDepartment of Radiology, Walter Reed National Military Medical Center, Bethesda, Maryland 20889.
Elizabeth KolbergDepartment of Hearing and Speech Sciences, University of Maryland, College Park, Maryland 20742.
Miranda ClearyDepartment of Hearing and Speech Sciences, University of Maryland, College Park, Maryland 20742.
Matthew J GoupellDepartment of Hearing and Speech Sciences, University of Maryland, College Park, Maryland 20742.

Funding

Model-based Cochlear Implant ProgrammingR01DC014037 · NIDCD · VANDERBILT UNIVERSITY · PI NOBLE, JACK · 2014 to 2024
$5.0M
Optimizing Bilateral and Single-Sided Deafness Cochlear Implants for Functioning in Complex Auditory EnvironmentsR01DC015798 · NIDCD · UNIV OF MARYLAND, COLLEGE PARK · PI BERNSTEIN, JOSHUA GARY, GOUPELL, MATTHEW J. · 2017 to 2021
$2.0M
NIDCD NIH HHS R01 DC014037NIDCD NIH HHS R01 DC015798
6 · The paper itself

Abstract

Bilateral cochlear implants (BI-CIs) or a CI for single-sided deafness (SSD-CI; one normally functioning acoustic ear) can partially restore spatial-hearing abilities, including sound localization and speech understanding in noise. For these populations, however, interaural place-of-stimulation mismatch can occur and thus diminish binaural sensitivity that relies on interaurally frequency-matched neurons. This study examined whether plasticity-reorganization of central neural pathways over time-can compensate for peripheral interaural place mismatch. We hypothesized differential plasticity across two systems: none for binaural processing but adaptation for pitch perception toward frequencies delivered by the specific electrodes. Interaural place mismatch was evaluated in 19 BI-CI and 23 SSD-CI human subjects (both sexes) using binaural processing (interaural-time-difference discrimination with simultaneous bilateral stimulation), pitch perception (pitch ranking for single electrodes or acoustic tones with sequential bilateral stimulation), and physical electrode-location estimates from computed-tomography (CT) scans. On average, CT scans revealed relatively little BI-CI interaural place mismatch (26° insertion-angle mismatch) but a relatively large SSD-CI mismatch, particularly at low frequencies (166° for an electrode tuned to 300 Hz, decreasing to 14° at 7000 Hz). For BI-CI subjects, the three metrics were in agreement because there was little mismatch. For SSD-CI subjects, binaural and CT measurements were in agreement, suggesting little binaural-system plasticity induced by mismatch. The pitch measurements disagreed with binaural and CT measurements, suggesting place-pitch plasticity or a procedural bias. These results suggest that reducing interaural place mismatch and potentially improving binaural processing by reprogramming the CI frequency allocation would be better done using CT-scan than pitch information.

Indexed as

Cochlear ImplantsAdaptation, PhysiologicalAdultAgedCochlear ImplantationFemaleHumansMaleMiddle AgedNeuronal PlasticityPitch PerceptionTomography, X-Ray Computedbinauralbrainsteminteraural time differencemismatchplasticitysuperior olivary complex

Identifiers

PMID34725189
PMCPMC8660045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.