Evidence map›Paper›PMID 34725165›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Differential phase register of Hes1 oscillations with mitoses underlies cell-cycle heterogeneity in ER

Nitin Sabherwal, Andrew Rowntree, Elli Marinopoulou, Tom Pettini, Sean Hourihane, Riba Thomas, Ximena Soto, Jochen Kursawe, Nancy Papalopulu

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. HES1 oscillations are required for cell cycle reentry in oestrogen receptor-positive breast cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Mathematical Modeling for Oscillations Driven by Noncoding RNAs.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Dynamic switching of lateral inhibition spatial patterns.Journal of the Royal Society, Interface · 2022
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nitin SabherwalDivision of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PT, United Kingdom; nancy.papalopulu@manchester.ac.uk Nitin.Sabherwal@imagentherapeutics.com.ORCID 0000-0002-5808-6201
Andrew RowntreeDivision of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PT, United Kingdom.ORCID 0000-0003-3220-0720
Elli MarinopoulouDivision of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PT, United Kingdom.ORCID 0000-0002-6379-5168
Tom PettiniDivision of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PT, United Kingdom.
Sean HourihaneDivision of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PT, United Kingdom.ORCID 0000-0001-8327-2578
Riba ThomasDivision of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PT, United Kingdom.
Ximena SotoDivision of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PT, United Kingdom.
Jochen KursaweSchool of Mathematics and Statistics, University of St Andrews, St Andrews KY16 9SS, United Kingdom.ORCID 0000-0002-0314-9623
Nancy PapalopuluDivision of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester M13 9PT, United Kingdom; nancy.papalopulu@manchester.ac.uk Nitin.Sabherwal@imagentherapeutics.com.
University of Manchester · GBUniversity of St Andrews · GB

Funding

Medical Research Council MR/L011840/1Wellcome TrustWellcome Trust 106185/Z/14/Z
6 · The paper itself

Abstract

Here, we study the dynamical expression of endogenously labeled Hes1, a transcriptional repressor implicated in controlling cell proliferation, to understand how cell-cycle length heterogeneity is generated in estrogen receptor (ER)

Indexed as

Cell CycleCircadian RhythmBreast NeoplasmsHumansMCF-7 CellsNeoplastic Stem CellsReceptors, EstrogenTranscription Factor HES-1HES1 protein, humanReceptors, EstrogenTranscription Factor HES-1cancer stem cell fatecell cycleHes1nongenetic heterogeneityoscillations

Identifiers

PMID34725165
PMCPMC8609326
OpenAlexW3209752342

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.