Evidence map›Paper›PMID 34724858›Full record

ArticleGut microbes

Pathobionts: mechanisms of survival, expansion, and interaction with host with a focus on

Harish Chandra, Krishna Kant Sharma, Olli H Tuovinen, Xingmin Sun, Pratyoosh Shukla

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Review
  3. Journal of bacteriology · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. The hallmarks of host-microbiome decoupling.Frontiers in microbiology · 2026
    Review
  11. Expansion resistance against genotoxicFrontiers in microbiology · 2026
    Article
  12. Correlation Between Dysbiosis and Atrial Fibrillation: What's New?International journal of molecular sciences · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Shared metabolism between a bacterial and fungal species that reside in the human gut.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Microbial dysbiosis and immune dysregulation in periodontitis and peri-implantitis.Frontiers in cellular and infection microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Harish ChandraDepartment of Environmental Microbiology, School of Earth and Environmental Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India.ORCID 0000-0002-6088-6152
Krishna Kant SharmaLaboratory of Enzymology and Recombinant DNA Technology, Department of Microbiology, Maharshi Dayanand University, Rohtak, Haryana, India.ORCID 0000-0001-9576-342X
Olli H TuovinenDepartment of Microbiology, Ohio State University, Columbus, OH, USA.ORCID 0000-0003-4601-4013
Xingmin SunDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.ORCID 0000-0002-8900-9161
Pratyoosh ShuklaSchool of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi, India.ORCID 0000-0002-9307-4126
Maharshi Dayanand University · INBabasaheb Bhimrao Ambedkar University · INThe Ohio State University · USUniversity of South Florida · US

Funding

Multivalent vaccines against Clostridium difficile infectionR01AI132711 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI Xingmin Sun, Shifeng Wang · 2017 to 2026
$3.3M
Novel polymer biomaterials combating C. difficile infectionR01AI149852 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CAI, JIANFENG, SUN, XINGMIN · 2019 to 2023
$1.9M
NIAID NIH HHS R01 AI132711NIAID NIH HHS R01 AI149852
6 · The paper itself

Abstract

Pathobionts are opportunistic microbes that emerge as a result of perturbations in the healthy microbiome due to complex interactions of various genetic, exposomal, microbial, and host factors that lead to their selection and expansion. Their proliferations can aggravate inflammatory manifestations, trigger autoimmune diseases, and lead to severe life-threatening conditions. Current surge in microbiome research is unwinding these complex interplays between disease development and protection against pathobionts. This review summarizes the current knowledge of pathobiont emergence with a focus on

Indexed as

Host-Pathogen InteractionsAnimalsClostridioides difficileClostridium InfectionsGastrointestinal MicrobiomeHumansTh17 CellsDysbiosisinflammasomeinflammatory bowel diseaseinnate lymphoid cellspseudomembranous colitistoxins

Identifiers

PMID34724858
PMCPMC8565823
OpenAlexW3209771172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.