ArticlemBio2021
Plasmodium falciparum Calcium-Dependent Protein Kinase 4 is Critical for Male Gametogenesis and Transmission to the Mosquito Vector.
Open access · goldAbstract read
In one paragraph
Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Phosphorylation in theJournal of proteome research · 2024Pooled it
- Functional analyses of male-specific early-phosphorylated proteins reveal an intrinsically disordered protein required for microgamete release inFrontiers in cellular and infection microbiology · 2026Article
- An MKT1 domain protein is dispensable for erythrocytic stages ofFrontiers in microbiology · 2026Article
- Molecular mechanisms involved inFrontiers in microbiology · 2026Review
- De Novo Molecular Design and Bioactivity Prediction of Novel Hexahydroquinolines asBioinformatics and biology insights · 2026Article
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- Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite Plasmodium berghei.PLoS pathogens · 2025Article
- Versatile Imidazole Scaffold with Potent Activity against Multiple Apicomplexan Parasites.ACS infectious diseases · 2025Article
- DivergentLife science alliance · 2025Article
- Advances in the dissection of Anopheles-Plasmodium interactions.PLoS pathogens · 2025Review
- Article
- Targeting Malaria's Achilles' Heels: A Review of Plasmodium Life Cycle Vulnerabilities for Drug Discovery.Current topics in medicinal chemistry · 2025Review
- Structure-based virtual screening against multiple Plasmodium falciparum kinases reveals antimalarial compounds.Molecular diversity · 2024Article
- Plasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation.PLoS biology · 2024Article
- Proteomic approaches for protein kinase substrate identification in Apicomplexa.Molecular and biochemical parasitology · 2024Review
- The molecular mechanisms driving Plasmodium cell division.Biochemical Society transactions · 2024Review
- FromiScience · 2024Article
- In silico prediction and in vitro assessment of novel heterocyclics with antimalarial activity.Parasitology research · 2023Article
- Transcriptomic approaches for identifying potential transmission blocking vaccine candidates in3 Biotech · 2023Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Sudhir Kumar *Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.ORCID 0000-0002-2847-393X
Meseret T HaileCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Michael R HoopmannInstitute for Systems Biology, Seattle, Washington, USA.ORCID 0000-0001-7029-7792
Linh T TranDepartment of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, Washington, USA.ORCID 0000-0002-9626-9439
Samantha A MichaelsDepartment of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, Washington, USA.ORCID 0000-0002-3386-5233
Seamus R MorroneInstitute for Systems Biology, Seattle, Washington, USA.ORCID 0000-0001-6454-8970
Kayode K OjoDepartment of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, Washington, USA.ORCID 0000-0002-2007-2170
Laura M ReynoldsCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Ulrike KusebauchInstitute for Systems Biology, Seattle, Washington, USA.ORCID 0000-0001-6162-7577
Ashley M VaughanCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.ORCID 0000-0001-5815-756X
Robert L MoritzInstitute for Systems Biology, Seattle, Washington, USA.ORCID 0000-0002-3216-9447
Stefan H I KappeCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.ORCID 0000-0003-1540-1731
Kristian E Swearingen *Institute for Systems Biology, Seattle, Washington, USA.ORCID 0000-0002-6756-4471
Infectious Disease Research Institute · USInstitute for Systems Biology · USUniversity of Washington · US
Funding
Shortening the development cycle time of Trans Proteomic Pipeline tools with high performance computingR01GM087221 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI DEUTSCH, ERIC, MORITZ, ROBERT L · 2010 to 2021
$6.0MElucidating the role of TSR glycosylation in Plasmodium parasitesR01AI148489 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI SWEARINGEN, KRISTIAN EDWARD · 2020 to 2024
$4.2MElucidating phosphorylation signaling networks in infectious Plasmodium parasitesK25AI119229 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI SWEARINGEN, KRISTIAN EDWARD · 2015 to 2019
$682kAcquisition of Fusion Lumos Orbitrap mass spectrometerS10OD026936 · OD · INSTITUTE FOR SYSTEMS BIOLOGY · PI MORITZ, ROBERT L · 2019 to 2019
$600kCoformulation of bumped kinase inhibitors with Artemisinin combination therapy will stop widespread transmission of artemisinin-resistant malaria strainsR21AI123690 · NIAID · UNIVERSITY OF WASHINGTON · PI OJO, KAYODE K · 2017 to 2018
$490kNIAID NIH HHS K25 AI119229NIAID NIH HHS R01 AI148489NIAID NIH HHS R21 AI123690NIGMS NIH HHS R01 GM087221NIH HHS S10 OD026936
Abstract
Gametocytes of the malaria parasite
Indexed as
Mosquito VectorsAnimalsCalcium-Calmodulin-Dependent Protein KinasesCalcium SignalingCulicidaeGametogenesisGerm CellsLife Cycle StagesMalaria, FalciparumMalePhosphorylationPlasmodium falciparumProtozoan ProteinsCalcium-Calmodulin-Dependent Protein KinasesProtozoan ProteinsexflagellationgametocytemosquitoPfCDPK4phosphoproteometransmission
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.