Evidence map›Paper›PMID 34724816›Full record

ArticlemBio2021

Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier.

Neeta Shrestha, Flavio Max Gall, Cyrille Mathieu, Melanie Michaela Hierweger, Melanie Brügger, Marco P Alves, Jonathan Vesin, Damiano Banfi, David Kalbermatter, Branka Horvat and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Emerging microbes & infections · 2025
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Neeta Shrestha *Division of Neurological Sciences, Vetsuisse Faculty, University of Berngrid.5734.5, Bern, Switzerland.
Flavio Max Gall *Institute of Chemistry and Biotechnology, Center for Organic and Medicinal Chemistry, Zurich University of Applied Sciences (ZHAW), Wädenswil, Switzerland.ORCID 0000-0001-5243-1521
Cyrille MathieuCIRI, Centre International de Recherche en Infectiologie, Team Immunobiology of the Viral Infections, Univ Lyon, INSERM, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.ORCID 0000-0002-6682-2029
Melanie Michaela HierwegerDivision of Neurological Sciences, Vetsuisse Faculty, University of Berngrid.5734.5, Bern, Switzerland.
Melanie BrüggerInstitute of Virology and Immunology, Bern, Switzerland.
Marco P AlvesInstitute of Virology and Immunology, Bern, Switzerland.
Jonathan VesinBiomolecular Screening Facility, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Damiano BanfiBiomolecular Screening Facility, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
David KalbermatterInstitute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Berngrid.5734.5, Bern, Switzerland.
Branka HorvatCIRI, Centre International de Recherche en Infectiologie, Team Immunobiology of the Viral Infections, Univ Lyon, INSERM, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon, France.ORCID 0000-0003-0578-7765
Marc ChambonBiomolecular Screening Facility, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Gerardo TurcattiBiomolecular Screening Facility, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Dimitrios FotiadisInstitute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Berngrid.5734.5, Bern, Switzerland.
Rainer RiedlInstitute of Chemistry and Biotechnology, Center for Organic and Medicinal Chemistry, Zurich University of Applied Sciences (ZHAW), Wädenswil, Switzerland.ORCID 0000-0003-2534-1963
Philippe PlattetDivision of Neurological Sciences, Vetsuisse Faculty, University of Berngrid.5734.5, Bern, Switzerland.ORCID 0000-0003-3313-2598
University of Bern · CHÉcole Polytechnique Fédérale de Lausanne · CHUniversité Claude Bernard Lyon 1 · FRZHAW Zurich University of Applied Sciences · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple enveloped RNA viruses of the family

Indexed as

Antiviral AgentsDrug DiscoveryHumansParamyxoviridaeParamyxoviridae InfectionsPneumovirusPneumovirus InfectionsVirus ReplicationAntiviral Agentshigh resistance barrierhost-directedinhibitorsparamyxoviruspneumovirusreplication

Identifiers

PMID34724816
PMCPMC8561388
OpenAlexW3208278417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.