Evidence map›Paper›PMID 34724814›Full record

ArticlemBio2021

Minor Alterations in Core Promoter Element Positioning Reveal Functional Plasticity of a Bacterial Transcription Factor.

Wamiah P Chowdhury, Kenneth A Satyshur, James L Keck, Patricia J Kiley

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Fe-S cluster homeostasis and beyond: The multifaceted roles of IscR.Biochimica et biophysica acta. Molecular cell research · 2024
    Review
  4. Using genome-wide expression compendia to study microorganisms.Computational and structural biotechnology journal · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wamiah P ChowdhuryDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Kenneth A SatyshurDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
James L KeckDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-5961-0220
Patricia J KileyDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-8771-1782
University of Wisconsin–Madison · US

Funding

Bacterial anaerobic iron homeostasisR01GM115894 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KILEY, PATRICIA J · 2015 to 2018
$1.2M
NIGMS NIH HHS R01 GM115894
6 · The paper itself

Abstract

IscR is a global transcription factor that regulates Fe-S cluster homeostasis and other functions in Escherichia coli by either activating or repressing transcription. While the interaction of IscR with its DNA sites has been studied, less is known about the mechanism of IscR regulation of transcription. Here, we show that IscR recruits RNA polymerase to an activated promoter and that IscR binding compensates for the lack of an optimal RNA polymerase σ

Indexed as

Gene Expression Regulation, BacterialPromoter Regions, GeneticTranscription, GeneticDNA-Directed RNA PolymerasesEscherichia coliEscherichia coli ProteinsProtein BindingProtein Conformation, alpha-HelicalTranscription FactorsDNA-Directed RNA PolymerasesEscherichia coli ProteinsIscR protein, E coliTranscription FactorsEscherichia coli gene expressionIscRtranscriptional regulationtranscriptional repression

Identifiers

PMID34724814
PMCPMC8561392
OpenAlexW3210431122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.