Evidence map›Paper›PMID 34724813›Full record

ArticlemBio2021

Bacterial Filamentation Drives Colony Chirality.

Andrés Aranda-Díaz, Cecilia Rodrigues, Alexandra Grote, Jiawei Sun, Carl Schreck, Oskar Hallatschek, Anton Souslov, Wolfram Möbius, Kerwyn Casey Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Chiral gliding: Right-handed navigation of filamentous cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Andrés Aranda-DíazDepartment of Bioengineering, Stanford Universitygrid.168010.e, Stanford, California, USA.ORCID 0000-0002-0566-4901
Cecilia RodriguesLiving Systems Institute, University of Exeter, Exeter, United Kingdom.
Alexandra GroteDepartment of Bioengineering, Stanford Universitygrid.168010.e, Stanford, California, USA.
Jiawei SunDepartment of Bioengineering, Stanford Universitygrid.168010.e, Stanford, California, USA.
Carl SchreckDepartment of Physics, University of California at Berkeley, Berkeley, California, USA.
Oskar HallatschekDepartment of Physics, University of California at Berkeley, Berkeley, California, USA.
Anton SouslovDepartment of Physics, University of Bath, Bath, United Kingdom.
Wolfram MöbiusLiving Systems Institute, University of Exeter, Exeter, United Kingdom.
Kerwyn Casey HuangDepartment of Bioengineering, Stanford Universitygrid.168010.e, Stanford, California, USA.ORCID 0000-0002-8043-8138
Stanford University · USUniversity of California, Berkeley · USUniversity of Exeter · GBChan Zuckerberg Initiative (United States) · USUniversity of Bath · GB

Funding

Resolving the Mechano-Chemical Regulation of Microbial Populations in Microfluidic DevicesR01GM115851 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HALLATSCHEK, OSKAR · 2015 to 2023
$2.2M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM115851
6 · The paper itself

Abstract

Chirality is ubiquitous in nature, with consequences at the cellular and tissue scales. As Escherichia coli colonies expand radially, an orthogonal component of growth creates a pinwheel-like pattern that can be revealed by fluorescent markers. To elucidate the mechanistic basis of this colony chirality, we investigated its link to left-handed, single-cell twisting during E. coli elongation. While chemical and genetic manipulation of cell width altered single-cell twisting handedness, colonies ceased to be chiral rather than switching handedness, and anaerobic growth altered colony chirality without affecting single-cell twisting. Chiral angle increased with increasing temperature even when growth rate decreased. Unifying these findings, we discovered that colony chirality was associated with the propensity for cell filamentation. Inhibition of cell division accentuated chirality under aerobic growth and generated chirality under anaerobic growth. Thus, regulation of cell division is intrinsically coupled to colony chirality, providing a mechanism for tuning macroscale spatial patterning.

Indexed as

AnaerobiosisBiomechanical PhenomenaCell DivisionCell WallEscherichia coliStereoisomerismA22anaerobic growthcell wallcephalexinchiralitycolony growthMreBpeptidoglycantemperaturetwisting

Identifiers

PMID34724813
PMCPMC8561393
OpenAlexW3208799661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.