Evidence map›Paper›PMID 34724762›Full record

ArticleThe Korean journal of parasitology2021

Expression of Chicken NK-Lysin and Its Role in Chicken Coccidiosis Induced by Eimeria necatrix.

Woo Hyun Kim, Wongi Min, Kwang Il Park, Hyun S Lillehoj, Cherry P Fernandez-Colorado, Rochelle A Flores, Paula Leona T Cammayo, Binh Thanh Nguyen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of parasitology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. UnderstandingFrontiers in cellular and infection microbiology · 2026
    Review
  4. Exploring the interplay betweenThe veterinary quarterly · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Woo Hyun KimCollege of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Korea.
Wongi MinCollege of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Korea.
Kwang Il ParkCollege of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Korea.
Hyun S LillehojAnimal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, ARS, U.S. Department of Agriculture, Beltsville, MD 20705, USA.
Cherry P Fernandez-ColoradoDepartment of Veterinary Paraclinical Sciences, College of Veterinary Medicine, University of the Philippines Los Baños, College, Laguna 4031, Philippines.
Rochelle A FloresCollege of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Korea.
Paula Leona T CammayoCollege of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Korea.
Binh Thanh NguyenCollege of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Korea.
Gyeongsang National University · KRBeltsville Agricultural Research Center · USUniversity of the Philippines Los Baños · PH

Funding

Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries
6 · The paper itself

Abstract

Coccidiosis in chickens is an intestinal parasitic disease caused by protozoan parasites named Eimeria spp. In some Eimeria infections, intestinal lymphocytes are known to highly express chicken NK-lysin (cNK-lysin), an antimicrobial peptide with anticoccidial activity. Therefore, this study aims to investigate the expression of cNK-lysin in E. necatrix-infected chickens and its role in E. necatrix infection. The expression of cNK-lysin transcript was significantly increased in E. necatrix sporozoites-treated lymphocytes. In E. necatrix infection, cNK-lysin transcript was induced in intestinal lymphocytes but not in the spleen. The recombinant cNK-lysin exhibited anticoccidial activity against E. necatrix sporozoites as well as immunomodulatory activity on macrophages by inducing proinflammatory cytokines. These results indicated that E. necatrix infection induces high local expression of cNK-lysin and the secreted cNK-lysin helps protect coccidiosis.

Indexed as

CoccidiosisEimeriaPoultry DiseasesAnimalsChickensProteolipidsNK-lysinProteolipidsantimicrobial peptidechickencoccidiosisEimeria necatrixNK-lysin

Identifiers

PMID34724762
PMCPMC8561051
OpenAlexW3208887571

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.