Evidence map›Paper›PMID 34724626›Full record

ArticleThe American journal of tropical medicine and hygiene2021

Clinical, Sociodemographic and Environmental Risk Factors for Acute Bacterial Diarrhea among Adults and Children over Five Years in Bangladesh.

Sabiha Nasrin, Stephanie C Garbern, Monique Gainey, Samika Kanekar, Mahmuda Monjory, Dilruba Ahmed, Kexin Qu, Tzu-Chun Chu, Christopher H Schmid, Eric J Nelson and 3 more

Open access · greenAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Sabiha NasrinInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Stephanie C GarbernDepartment of Emergency Medicine, Alpert Medical School, Brown University, Providence, Rhode Island.
Monique GaineyDepartment of Emergency Medicine, Rhode Island Hospital, Providence, Rhode Island.
Samika KanekarBrown University, Providence, Rhode Island.
Mahmuda MonjoryInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Dilruba AhmedInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Kexin QuDepartment of Biostatistics, Brown University School of Public Health, Providence, Rhode Island.
Tzu-Chun ChuCenter for Statistical Sciences, Brown University, Providence, Rhode Island.
Christopher H SchmidDepartment of Biostatistics, Brown University School of Public Health, Providence, Rhode Island.
Eric J NelsonDepartments of Pediatrics and Environmental and Global Health, University of Florida, Gainesville, Florida.
Tahmeed AhmedInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Nur H AlamInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Adam C LevineDepartment of Emergency Medicine, Alpert Medical School, Brown University, Providence, Rhode Island.
Brown University · USInternational Centre for Diarrhoeal Disease Research · BDRhode Island Hospital · USUniversity of Florida · US

Funding

Tracking and Evaluation CoreU54GM115677 · NIGMS · BROWN UNIVERSITY · PI TUULI, METHODIUS GAMUO · 2016 to 2025
$45.0M
External Validation and Implementation of a Novel Mobile Health Application for Acute Diarrhea Management across the LifespanR01DK116163 · NIDDK · RHODE ISLAND HOSPITAL · PI Adam Carl Levine · 2018 to 2026
$4.7M
NIDDK NIH HHS R01 DK116163NIGMS NIH HHS U54 GM115677
6 · The paper itself

Abstract

In 2016, diarrheal disease was the eighth leading cause of mortality globally accounting for over 1.6 million deaths with the majority of deaths in adults and children over 5 years. This study aims to investigate the clinical, sociodemographic, and environmental risk factors associated with common bacterial acute diarrhea among adults and children over 5. Data were collected from March 2019 to March 2020 in patients over 5 years presenting with acute gastroenteritis at icddr,b. Stool samples were collected from each patient for culture and polymerase chain reaction (PCR) testing. Bivariate associations between independent variables and stool-testing indicating bacterial etiology were calculated. This analysis included 2,133 diarrheal patients of whom a bacterial enteropathogen was identified in 1,537 (72%). Detection of bacteria was associated with: younger age (OR 0.92; 95% CI: 0.88-0.96), lower mean arterial pressure (OR 0.84; 95% CI: 0.79-0.89), heart rate (OR 1.06; 95% CI: 1.01-1.10), percentage dehydration (OR 1.33; 95% CI: 1.13-1.55), respiration rate (OR 1.23; 95% CI: 1.04-1.46), lower mid-upper arm circumference (OR 0.97; 95% CI: 0.94-0.99), confused/lethargic mental status (OR 1.85; 95% CI: 1.11-3.25), rice watery stool (OR 1.92; 95% CI: 1.54-2.41), and vomiting more than three times in the past 24 hours (OR 1.30; 95% CI: 1.06-1.58). Higher monthly income (OR 0.92; 95% CI: 0.86-0.98), > 8 years of education (OR 0.79; 95% CI: 0.63-1.00), and having more than five people living at home (OR 0.80; 95% CI: 0.66-0.98) were associated with lower odds of bacterial diarrhea. These findings may help guide the development of predictive tools to aid in identifying patients with bacterial diarrhea for timely and appropriate use of antibiotics.

Indexed as

Acute DiseaseAdolescentAdultAgedBacterial InfectionsBangladeshChildContact TracingDehydrationDiarrheaEnvironmentFamily CharacteristicsFemaleHumansMaleMiddle Aged

Identifiers

PMID34724626
PMCPMC8832925
OpenAlexW3208700165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.