Evidence map›Paper›PMID 34724391›Full record

ArticleAmerican journal of respiratory and critical care medicine2022

Lung Microenvironments and Disease Progression in Fibrotic Hypersensitivity Pneumonitis.

Laurens J De Sadeleer, John E McDonough, Jonas C Schupp, Xiting Yan, Arno Vanstapel, Anke Van Herck, Stephanie Everaerts, Vincent Geudens, Annelore Sacreas, Tinne Goos and 16 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Prognostic biomarkers for the development of progressive pulmonary fibrosis in hypersensitivity pneumonitis: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The role of vascularity and the fibrovascular interface in interstitial lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  10. Single-Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis.American journal of respiratory and critical care medicine · 2024
    Article
  11. Article
  12. Observational
  13. Increased ER Stress and Unfolded Protein Response Activation in Epithelial and Inflammatory Cells in Hypersensitivity Pneumonitis.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 9 institutions in 5 countries.

Laurens J De SadeleerLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA).ORCID 0000-0003-1237-7369
John E McDonoughLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA).ORCID 0000-0003-2497-0258
Jonas C SchuppPulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-7714-8076
Xiting YanPulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut.
Arno VanstapelLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA).
Anke Van HerckLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA).
Stephanie EveraertsLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA).
Vincent GeudensLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA).
Annelore SacreasLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA).
Tinne GoosLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA).ORCID 0000-0002-8081-333X
Celine AelbrechtLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA).
Tim S NawrotDepartment of Public Health and Primary Care, and.
Dries S MartensCentre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
Dominique ScholsDepartment of Microbiology, Immunology, and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
Sandra ClaesDepartment of Microbiology, Immunology, and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
Johny A VerschakelenDepartment of Radiology, University Hospitals Leuven, Leuven, Belgium.
Eric K VerbekenDepartment of Histopathology, and.
Maximilian AckermannInstitute of Functional and Clinical Anatomy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Anabelle DecottigniesTelomeres Research Group, Genetic and Epigenetic Alterations of Genomes, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
Manon MahieuTelomeres Research Group, Genetic and Epigenetic Alterations of Genomes, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
Tillie-Louise HackettCentre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada; and.
James C HoggCentre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada; and.
Bart M VanaudenaerdeLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA).
Stijn E VerledenLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA).ORCID 0000-0002-9656-5844
Naftali KaminskiPulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0001-5917-4601
Wim A WuytsLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism (CHROMETA).ORCID 0000-0001-9648-3497
Chest Diseases Hospital · KWYale University · USde Duve Institute · BEHasselt University · BERega Institute for Medical Research · BEUniversity of British Columbia · CAJohannes Gutenberg University Mainz · DEKU Leuven · BEUniversity of Antwerp · BE

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Genomic Analysis of Tissue and Cellular Heterogeneity in IPFR01HL127349 · NHLBI · YALE UNIVERSITY · PI BENOS, PANAGIOTIS V, KAMINSKI, NAFTALI · 2015 to 2025
$5.9M
Epithelial Protective Effects of Thyroid Hormone Signaling in FibrosisR01HL141852 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2019 to 2022
$3.4M
Normal Aging Lung Cell Atlas (NALCA)U01HL145567 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2019 to 2022
$2.8M
Mir-29 mimicry as a therapy for pulmonary fibrosisUH2HL123886 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2014 to 2015
$2.7M
Deep and Integrative Analysis of RNA Sequencing Data to Identify Pathogenesis Heterogeneity of Chronic Lung DiseaseR21LM012884 · NLM · YALE UNIVERSITY · PI YAN, XITING · 2018 to 2019
$415k
CIHRNCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL127349NHLBI NIH HHS R01 HL141852NHLBI NIH HHS U01 HL145567NHLBI NIH HHS UH2 HL123886NIH HHS R01HL127349NIH HHS R01HL141852NIH HHS R21LM012884NIH HHS U01HL145567NIH HHS UH2HL123886NLM NIH HHS R21 LM012884
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

TranscriptomeAdultAgedAlveolitis, Extrinsic AllergicCase-Control StudiesDisease ProgressionFemaleFibrosisGene Expression ProfilingGenetic MarkersHumansLinear ModelsLungMaleMiddle AgedReproducibility of ResultsGenetic Markersextrinsic allergic alveolitispulmonary fibrosistranscriptome

Identifiers

PMID34724391
PMCPMC8865586
OpenAlexW3209302925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.