Evidence map›Paper›PMID 34724387›Full record

ArticleInfection and immunity2022

Characterization of Pathogenic CD8

Zengzi Zhou, Qi Tian, Luying Wang, Xin Sun, Nu Zhang, Min Xue, Dabao Xu, Guangming Zhong

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Infectivity of a pathogenicity-attenuatedInfection and immunity · 2025
    Article
  3. Viral Vector-BasedVaccines · 2024
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Zengzi ZhouThe 3rd Xiangya Hospital, Central South Universitygrid.216417.7, Changsha, Hunan, China.
Qi TianDepartment of Medical Genetics, Maternal and Child Health Hospital of Hunan Province, Changsha, Hunan, China.
Luying WangThe 3rd Xiangya Hospital, Central South Universitygrid.216417.7, Changsha, Hunan, China.
Xin SunThe 3rd Xiangya Hospital, Central South Universitygrid.216417.7, Changsha, Hunan, China.
Nu ZhangDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, Texas, USA.
Min XueThe 3rd Xiangya Hospital, Central South Universitygrid.216417.7, Changsha, Hunan, China.
Dabao XuThe 3rd Xiangya Hospital, Central South Universitygrid.216417.7, Changsha, Hunan, China.
Guangming ZhongDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, Texas, USA.ORCID 0000-0001-7053-5009
Central South University · CNThe University of Texas Health Science Center at San Antonio · USHunan Provincial Maternal and Child Health Hospital · CN

Funding

MECHANISMS OF CHLAMYDIAL EVASION OF IMMUNE RECOGNATIONR01AI047997 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2000 to 2021
$6.9M
Chlamydial plasmid-dependent pathogenesisR01AI121989 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2016 to 2019
$1.9M
Genital Chlamydia spreading to the gastrointestinal tract promotes chlamydial pathogenicity in the upper genital tractR21AI151724 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2020 to 2021
$416k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI047997NIAID NIH HHS R01 AI047997NIAID NIH HHS R01 AI121989NIAID NIH HHS R21 AI151724
6 · The paper itself

Abstract

Chlamydia trachomatis is a leading infectious cause of infertility in women due to its induction of lasting pathology such as hydrosalpinx. Chlamydia muridarum induces mouse hydrosalpinx because C. muridarum can both invade tubal epithelia directly (as a first hit) and induce lymphocytes to promote hydrosalpinx indirectly (as a second hit). In the current study, a critical role of CD8

Indexed as

AnimalsAntigens, BacterialBiopsyCD8-Positive T-LymphocytesChlamydia InfectionsChlamydia muridarumDisease Models, AnimalDisease SusceptibilityFemaleHost-Pathogen InteractionsMiceSalpingitisT-Lymphocyte SubsetsAntigens, BacterialCD8+ T cellsChlamydiaGastrointestinal Chlamydiagastrointestinal colonizationhydrosalpinxtwo-hit hypothesis

Identifiers

PMID34724387
PMCPMC8788780
OpenAlexW3208681013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.