Evidence map›Paper›PMID 34724360›Full record

ArticleObesity (Silver Spring, Md.)2021

Brain responses to glucose ingestion are greater in children than adults and are associated with overweight and obesity.

Brandon B Ge, Kay Jann, Shan Luo, Alexandra G Yunker, Sabrina Jones, Brendan Angelo, Jasmin M Alves, Alexis Defendis, John R Monterosso, Anny H Xiang and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Brandon B GeDivision of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-8775-8521
Kay JannMark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Shan LuoDivision of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Alexandra G YunkerDivision of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Sabrina JonesDivision of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0001-8253-5145
Brendan AngeloDivision of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jasmin M AlvesDivision of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Alexis DefendisDivision of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
John R MonterossoDepartment of Psychology, University of Southern California, Los Angeles, California, USA.
Anny H XiangDepartment of Research and Evaluation, Kaiser Permanente Southern California, Los Angeles, California, USA.ORCID 0000-0003-2786-1268
Kathleen A PageDivision of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-9083-6615
University of Southern California · USKaiser Permanente · US

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Neuroendocrine Systems involved in Early-life Programming for Obesity and DiabetesR01DK116858 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PAGE, KATHLEEN ALANNA, XIANG, ANNY H · 2019 to 2023
$3.5M
Neural Mechanisms for Appetitive Responses to High Reward FoodsR01DK102794 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PAGE, KATHLEEN ALANNA · 2016 to 2020
$2.7M
Neural Mechanisms of Overeating Among Children Exposed to Gestational Diabetes Mellitus In UteroK01DK115638 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LUO, SHAN · 2018 to 2021
$758k
Neural mechanisms for obestity risk in children exposed to diabetes in uteroR03DK103083 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PAGE, KATHLEEN ALANNA · 2014 to 2015
$165k
NCATS NIH HHS UL1 TR001855NIDDK NIH HHS K01 DK115638NIDDK NIH HHS K01DK115638NIDDK NIH HHS R01 DK102794NIDDK NIH HHS R01 DK116858NIDDK NIH HHS R01DK116858NIDDK NIH HHS R03 DK103083NIDDK NIH HHS R03DK103083Southern California Clinical and Translational Science Institute UL1TR001855
6 · The paper itself

Abstract

objectiveThis study investigated whether brain regions involved in the regulation of food intake respond differently to glucose ingestion in children and adults and the relationship between brain responses and weight status.

methodsData included 87 children (ages 7-11 years) and 94 adults (ages 18-35 years) from two cohorts. Healthy weight, overweight, and obesity were defined by Centers for Disease Control and Prevention criteria. Brain responses to glucose were determined by measuring cerebral blood flow using arterial spin labeling magnetic resonance imaging in brain regions involved in the regulation of eating behavior.

resultsChildren showed significantly larger increases in brain responses to glucose than adults in the dorsal striatum (p < 0.01), insula (p < 0.01), hippocampus (p < 0.01), and dorsal-lateral prefrontal cortex (p < 0.01). Responses to glucose in the dorsal striatum (odds ratio [OR] = 1.52, 95% CI 1.05-2.20; p = 0.03), hippocampus (OR = 1.51, 95% CI: 1.02-2.22; p = 0.04), insula (OR = 1.64, 95% CI: 1.11-2.42; p = 0.01), and orbitofrontal cortex (OR = 1.63 95% CI: 1.12-2.39; p = 0.01) were positively associated with overweight or obesity, independent of age group.

conclusionsChildren have greater brain responses to glucose ingestion than adults in regions involved in eating behavior, and these responses are associated with weight status.

Indexed as

GlucoseOverweightAdolescentAdultBrainChildEatingHumansMagnetic Resonance ImagingObesityYoung AdultGlucose

Identifiers

PMID34724360
PMCPMC11779493
OpenAlexW3209591688

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.