ArticleCancer2022
Prevalence and risk factors of cancer-related fatigue in childhood cancer survivors: A DCCSS LATER study.
Article in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Grading the evidence on the effects of exercise interventions in children and adolescents during and beyond cancer treatment: an umbrella review of systematic reviews with meta-analyses.British journal of sports medicine · 2026Pooled it
- Barriers and facilitators associated with long-term follow-up care for childhood, adolescent, and young adult cancer survivors: a systematic review.BMC health services research · 2025Pooled it
- Trial
- Pain Predicts Next-Day Fatigue in Adolescents and Young Adults Receiving Maintenance Treatment for Acute Lymphoblastic Leukemia.Journal of adolescent and young adult oncology · 2026Article
- A new screening tool for determining occupational therapy needs in hospitalized children with cancer: a validity and reliability study.European journal of pediatrics · 2026Article
- Health Behaviors in Adolescent and Young Adult (AYA) Childhood Cancer Survivors: Prevalence, Determinants, and Comparison With Population Controls.Cancer medicine · 2026Article
- Prevalence and associated factors of poor lifestyle behaviours in survivors of childhood cancer: a PanCareFollowUp substudy.Journal of cancer survivorship : research and practice · 2026Article
- Structural equation modeling to explore putative causal factors for chronic fatigue in childhood cancer survivors: a DCCSS LATER study.Journal of cancer survivorship : research and practice · 2026Article
- Weekly physical activity trajectories in short- and long-term survivors of childhood cancer: the PACCS and SURfit studies.Journal of cancer survivorship : research and practice · 2026Article
- Mental Distress, Fatigue and Executive Function in Adult Survivors of Childhood Leukemia and Non-Hodgkin Lymphoma.Current oncology (Toronto, Ont.) · 2026Article
- Fatigue after pediatric bone sarcoma: prevalence and associated factors in pediatric and adult patients and survivors after treatment.Journal of cancer survivorship : research and practice · 2026Article
- Self-reported physical fitness domains and perceptions of exercise and fatigue among childhood cancer survivors.JSAMS plus · 2026Article
- Physical activity after local therapy for pediatric bone sarcoma: an accelerometry-based analysis.Journal of cancer survivorship : research and practice · 2026Article
- European recommendations for short-term surveillance of health problems in childhood, adolescent and young adult cancer survivors from the end of treatment to 5 years after diagnosis: a PanCare guideline.Journal of cancer survivorship : research and practice · 2025Article
- Sleep quality and physical fitness as modifiable contributors of fatigue in childhood cancer survivors.Journal of cancer survivorship : research and practice · 2025Article
- Parental Reports on Late Effects and Follow-Up Needs: A Single-Center Assessment of Childhood Cancer Survivorship Care in Kenya.Current oncology (Toronto, Ont.) · 2025Article
- Efficacy of the PanCareFollowUp eHealth Lifestyle Intervention for Survivors of Childhood, Adolescent and Young Adult Cancer.Cancer medicine · 2025Article
- Metabolic Implications of Childhood Cancer.Current pediatrics reports · 2025Article
- Article
- Barriers and facilitators to implementation of the interoperable Survivorship Passport (SurPass) v2.0 in 6 European countries: a PanCareSurPass online survey study.Journal of cancer survivorship : research and practice · 2024Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
backgroundCancer-related fatigue is a debilitating late effect after treatment for childhood cancer. The prevalence of fatigue in childhood cancer survivors (CCSs) and associated factors for fatigue has varied widely in previous studies. Two important aspects of cancer-related fatigue, its severity and chronicity, are often not assessed. This study investigated the prevalence of, and risk factors for, severe chronic fatigue (CF) in a national cohort of Dutch CCSs.
methodsIn this study, 2810 CCSs (5-year survivors of all childhood malignancies diagnosed between 1963 and 2001 with a current age of 12-65 years) and 1040 sibling controls were included. CF was assessed with the Short Fatigue Questionnaire and was defined as a score ≥ 18 and persistence of fatigue for ≥6 months. Cancer- and treatment-related characteristics, current health problems, and demographic and lifestyle variables were assessed as potential risk factors for CF via multivariable logistic regression analyses.
resultsIn adult CCSs and sibling controls (≥18 years old), the prevalence of CF was 26.1% and 14.1%, respectively (P < .001). In adolescent CCSs and sibling controls (<18 years old), the prevalence of CF was 10.9% and 3.2%, respectively. Female gender (odds ratio [OR], 2.13; 95% confidence interval [CI], 1.73-2.62), unemployment (OR, 2.18; 95% CI, 1.67-2.85), having 1 or more health problems (OR for 1-2, 1.48; 95% CI, 1.18-1.87; OR for >2, 2.20; 95% CI, 1.50-3.21), and a central nervous system diagnosis (OR, 1.74; 95% CI, 1.17-2.60) were significantly associated with CF in adult CCSs.
conclusionsThis study shows that CCSs, regardless of their cancer diagnosis, report CF more often than sibling controls. This study provides new evidence for the prevalence of fatigue in CCSs.
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