Evidence map›Paper›PMID 34724200›Full record

ArticleInternational journal of cancer2022

Citrus-Gene interaction and melanoma risk in the UK Biobank.

Andrew R Marley, Ming Li, Victoria L Champion, Yiqing Song, Jiali Han, Xin Li

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Systematic review on gene-sun exposure interactions in skin cancer.Molecular genetics & genomic medicine · 2023
    Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Andrew R MarleyDepartment of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana, USA.ORCID 0000-0002-1699-5589
Ming LiDepartment of Epidemiology and Biostatistics, Indiana University School of Public health, Bloomington, Indiana, USA.
Victoria L ChampionDepartment of Community Health Systems, Indiana University School of Nursing, Indianapolis, Indiana, USA.
Yiqing SongDepartment of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana, USA.
Jiali HanDepartment of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana, USA.
Xin LiDepartment of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana, USA.ORCID 0000-0002-0135-8800
Indiana University Health · USIndiana University – Purdue University Indianapolis · USIndiana University Bloomington · US

Funding

Translational Pediatric Cancer Epidemiology Research Training GrantT32CA099936 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Logan G. Spector · 2004 to 2026
$5.1M
Interdisciplinary Training in Cancer Prevention and ControlT32CA117865 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI Victoria Lee Champion, Catherine E Mosher · 2016 to 2026
$2.4M
Random Field Modelling of genetic and epigenetic association underlying congenital heart defects in the presence of disease heterogeneityK01HL140333 · NHLBI · TRUSTEES OF INDIANA UNIVERSITY · PI LI, MING · 2018 to 2021
$724k
Gene-by-Gene and Gene-by-Environment Interactions Underlying Congenital Heart DefectsR03HD092854 · NICHD · TRUSTEES OF INDIANA UNIVERSITY · PI LI, MING · 2018 to 2019
$171k
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NCI NIH HHS T32 CA099936NCI NIH HHS T32 CA117865NHLBI NIH HHS K01HL14033NHLBI NIH HHS K01 HL140333NICHD NIH HHS R03 HD092854
6 · The paper itself

Abstract

High citrus consumption may increase melanoma risk; however, little is known about the biological mechanisms of this association, or whether it is modified by genetic variants. We conducted a genome-wide analysis of gene-citrus consumption interactions on melanoma risk among 1563 melanoma cases and 193 296 controls from the UK Biobank. Both the 2-degrees-of-freedom (df) joint test of genetic main effect and gene-environment (G-E) interaction and the standard 1-df G-E interaction test were performed. Three index SNPs (lowest P-value SNP among highly correlated variants [r

Indexed as

Gene-Environment InteractionCitrusCyclin-Dependent Kinase Inhibitor p16Genome-Wide Association StudyHumansMelanomaMicrophthalmia-Associated Transcription FactorPolymorphism, Single NucleotidePurine-Nucleoside PhosphorylaseRisk5'-methylthioadenosine phosphorylaseCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16Microphthalmia-Associated Transcription FactorMITF protein, humanPurine-Nucleoside Phosphorylasecitrusgene-environment interactionGWASmelanoma

Identifiers

PMID34724200
PMCPMC10015424
OpenAlexW3210774243

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.