ArticlePLoS genetics2021
Engines of change: Transposable element mutation rates are high and variable within Daphnia magna.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Dislodging the drift barrier: Why do mutation rates vary?Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Spontaneous Mutations Occur More in Highly Transcribed Regions in Daphnia.Genome biology and evolution · 2026Article
- Chromosomal Rearrangements and Transposable Elements in Locally Adapted Island Drosophila.Genome biology and evolution · 2026Article
- Unravelling High Nuclear Genomic Similarity and Mitochondria Linked Epigenetic Divergence in SCNT Derived Buffalo Clones via Long-Read Nanopore Genome Sequencing.International journal of molecular sciences · 2025Article
- Mutations of short tandem repeats explain abundant trait heritability in Arabidopsis.Genome biology · 2025Article
- Causes and Consequences of Varying Transposable Element Activity: An Evolutionary Perspective.Annual review of genomics and human genetics · 2024Review
- Environment-induced heritable variations are common in Arabidopsis thaliana.Nature communications · 2024Article
- Blessing or curse: how the epigenetic resolution of host-transposable element conflicts shapes their evolutionary dynamics.Proceedings. Biological sciences · 2024Article
- Forces driving transposable element load variation during Arabidopsis range expansion.The Plant cell · 2024Article
- The effects of mutations on gene expression and alternative splicing.Proceedings. Biological sciences · 2023Article
- Variation in mutation, recombination, and transposition rates inGenome research · 2023Article
- Rates and spectra of de novo structural mutations inGenome research · 2023Article
- Transposable elements and xenobiotic resistance.Frontiers in insect science · 2023Review
- Species-specific chromatin landscape determines how transposable elements shape genome evolution.eLife · 2022Article
- Thermal stress and mutation accumulation increase heat shock protein expression inEvolutionary ecology · 2022Article
- Intraspecific Variation in the Rates of Mutations Causing Structural Variation in Daphnia magna.Genome biology and evolution · 2021Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
Transposable elements (TEs) represent a major portion of most eukaryotic genomes, yet little is known about their mutation rates or how their activity is shaped by other evolutionary forces. Here, we compare short- and long-term patterns of genome-wide mutation accumulation (MA) of TEs among 9 genotypes from three populations of Daphnia magna from across a latitudinal gradient. While the overall proportion of the genome comprised of TEs is highly similar among genotypes from Finland, Germany, and Israel, populations are distinguishable based on patterns of insertion site polymorphism. Our direct rate estimates indicate TE movement is highly variable (net rates ranging from -11.98 to 12.79 x 10-5 per copy per generation among genotypes), differing both among populations and TE families. Although gains outnumber losses when selection is minimized, both types of events appear to be highly deleterious based on their low frequency in control lines where propagation is not limited to random, single-progeny descent. With rate estimates 4 orders of magnitude higher than base substitutions, TEs clearly represent a highly mutagenic force in the genome. Quantifying patterns of intra- and interspecific variation in TE mobility with and without selection provides insight into a powerful mechanism generating genetic variation in the genome.
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