ArticlePLoS computational biology2021
Nonlinear visuoauditory integration in the mouse superior colliculus.
Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Population decoding of sound source location by receptive field neurons in the mouse superior colliculus.bioRxiv : the preprint server for biology · 2026Article
- Nonlinear integration of sensory inputs and behavioral state by a single neuron in C. elegans.Current biology : CB · 2025Article
- Functional specialisation of multisensory temporal integration in the mouse superior colliculus.Nature communications · 2025Article
- Characterization of Auditory Responsive Neurons in the Mouse Superior Colliculus to White Noise and Frequency-Restricted Sounds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Review
- Cross-modal enhancement of defensive behavior via parabigemino-collicular projections.Current biology : CB · 2024Article
- Dynamic Nonlinear Spatial Integrations on Encoding Contrasting Stimuli of Tectal Neurons.Animals : an open access journal from MDPI · 2024Article
- Auditory cortex conveys non-topographic sound localization signals to visual cortex.Nature communications · 2024Article
- Multisensory integration in the mammalian brain: diversity and flexibility in health and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Article
- Deconvolution of the Functional Ultrasound Response in the Mouse Visual Pathway Using Block-Term Decomposition.Neuroinformatics · 2023Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
Sensory information from different modalities is processed in parallel, and then integrated in associative brain areas to improve object identification and the interpretation of sensory experiences. The Superior Colliculus (SC) is a midbrain structure that plays a critical role in integrating visual, auditory, and somatosensory input to assess saliency and promote action. Although the response properties of the individual SC neurons to visuoauditory stimuli have been characterized, little is known about the spatial and temporal dynamics of the integration at the population level. Here we recorded the response properties of SC neurons to spatially restricted visual and auditory stimuli using large-scale electrophysiology. We then created a general, population-level model that explains the spatial, temporal, and intensity requirements of stimuli needed for sensory integration. We found that the mouse SC contains topographically organized visual and auditory neurons that exhibit nonlinear multisensory integration. We show that nonlinear integration depends on properties of auditory but not visual stimuli. We also find that a heuristically derived nonlinear modulation function reveals conditions required for sensory integration that are consistent with previously proposed models of sensory integration such as spatial matching and the principle of inverse effectiveness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.