Evidence map›Paper›PMID 34723787›Full record

ArticleMicrobiology (Reading, England)2021

Colistin resistance in

Madeleine Humphrey, Gerald J Larrouy-Maumus, R Christopher D Furniss, Despoina A I Mavridou, Akshay Sabnis, Andrew M Edwards

Open access · hybridAbstract read
In one paragraph

Article in Microbiology (Reading, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Bacterial cell envelope-targeting antibiotics.Nature reviews. Microbiology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. ACS applied bio materials · 2025
    Article
  7. Microbiology spectrum · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. A review of the mechanisms that confer antibiotic resistance in pathotypes ofFrontiers in cellular and infection microbiology · 2024
    Review
  12. Prevalence and Antimicrobial Resistance ofAnimals : an open access journal from MDPI · 2023
    Article
  13. The battle against colistin-resistantNew microbes and new infections · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Polymyxin B1 within theBiophysical reviews · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Madeleine HumphreyMRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, SW7 2AZ, UK.
Gerald J Larrouy-MaumusMRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, SW7 2AZ, UK.
R Christopher D FurnissScience for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden.
Despoina A I MavridouDepartment of Molecular Biosciences, University of Texas at Austin, Austin, 78712, Texas, USA.
Akshay SabnisMRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, SW7 2AZ, UK.
Andrew M EdwardsMRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, SW7 2AZ, UK.
Imperial College London · GBStockholm University · SEThe University of Texas at Austin · US

Funding

Department of HealthMedical Research Council MC_PC_15028Medical Research Council MC_PC_17162Medical Research Council MR/M009505/1Medical Research Council MR/N014103/1Wellcome TrustWellcome Trust 105603/Z/14/Z
6 · The paper itself

Abstract

Colistin is a polymyxin antibiotic of last resort for the treatment of infections caused by multi-drug-resistant Gram-negative bacteria. By targeting lipopolysaccharide (LPS), the antibiotic disrupts both the outer and cytoplasmic membranes, leading to bacterial death and lysis. Colistin resistance in

Indexed as

ColistinEscherichia coli ProteinsAnti-Bacterial AgentsDrug Resistance, BacterialEscherichia coliMicrobial Sensitivity TestsPlasmidsPolymyxinsAnti-Bacterial AgentsColistinEscherichia coli ProteinsMCR-1 protein, E coliPolymyxinscolistinE. colilipopolysaccharideMCRpolymyxinresistance

Identifiers

PMID34723787
PMCPMC8743629
OpenAlexW3210351770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.