Evidence map›Paper›PMID 34723629›Full record

ArticleAntimicrobial agents and chemotherapy2022

Highly Conserved

Pierre L Bonnet, Solène Le Gal, Claire V Hoffmann, Florent Morio, Fouleymata Diabira, Athéna de Quélen, Guillaume Curral, Steven Negri, Virginie Cogulet, Jean-François Huon and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Pierre L BonnetLaboratoire de Parasitologie et Mycologie, Hôpital de La Cavale Blanche, CHU de Brest, Brest, France.
Solène Le GalLaboratoire de Parasitologie et Mycologie, Hôpital de La Cavale Blanche, CHU de Brest, Brest, France.
Claire V HoffmannLaboratoire de Parasitologie et Mycologie, Hôpital de La Cavale Blanche, CHU de Brest, Brest, France.
Florent MorioLaboratoire de Parasitologie et Mycologie, CHU de Nantes, Nantes, France.
Fouleymata DiabiraUniversité d'Angers, Université de Brest, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), France.
Athéna de QuélenUniversité d'Angers, Université de Brest, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), France.
Guillaume CurralUniversité d'Angers, Université de Brest, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), France.
Steven NegriUniversité d'Angers, Université de Brest, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), France.
Virginie CoguletPharmacie, Hôpital de La Cavale Blanche, CHU de Brest, Brest, France.
Jean-François HuonClinical Pharmacy Unit, CHU de Nantes, Nantes, France.ORCID 0000-0002-8738-4419
Matthieu GrégoireClinical Pharmacology Department, CHU Nantes and EE1701, Microbiotas Hosts Antibiotics and Bacterial Resistances, Nantes University, Nantes, France.ORCID 0000-0003-1232-5761
Nicolas PaponUniversité d'Angers, Université de Brest, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), France.ORCID 0000-0001-6265-7321
Patrice Le PapeLaboratoire de Parasitologie et Mycologie, CHU de Nantes, Nantes, France.
Jean-Philippe BoucharaUniversité d'Angers, Université de Brest, Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), France.
Gilles NevezLaboratoire de Parasitologie et Mycologie, Hôpital de La Cavale Blanche, CHU de Brest, Brest, France.ORCID 0000-0001-5888-6017
Université de Bretagne Occidentale · FRCentre Hospitalier Universitaire de Nantes · FRCentre Hospitalier Régional Universitaire de Brest · FRNantes Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Echinocandins are noncompetitive inhibitors of the GSC1 subunit of the enzymatic complex involved in synthesis of 1,3-beta-d-glucan, a cell wall component of most fungi, including Pneumocystis spp. Echinocandins are widely used for treating systemic candidiasis and rarely used for treating Pneumocystis pneumonia. Consequently, data on

Indexed as

PneumocystisPneumocystis cariniiPneumonia, PneumocystisCell WallEchinocandinsHumansEchinocandins1,3-beta-d-glucanechinocandinsgenomic diversitygsc1hot spotsPneumocystis jirovecii

Identifiers

PMID34723629
PMCPMC8765322
OpenAlexW3208085634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.