Evidence map›Paper›PMID 34723436›Full record

ArticleCancer medicine2021

Effects of marital status on survival of medullary thyroid cancer stratified by age.

Lei Ai, Ning Li, Hai-Long Tan, Bo Wei, Ya-Xin Zhao, Pei Chen, Hui-Yu Hu, Mian Liu, Deng-Jie Ou-Yang, Zi-En Qin and 2 more

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Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lei AiDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan, P.R. China.
Ning LiDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan, P.R. China.
Hai-Long TanDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan, P.R. China.
Bo WeiDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan, P.R. China.
Ya-Xin ZhaoDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan, P.R. China.
Pei ChenDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan, P.R. China.
Hui-Yu HuDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan, P.R. China.
Mian LiuDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan, P.R. China.
Deng-Jie Ou-YangDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan, P.R. China.
Zi-En QinDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan, P.R. China.
Peng HuangDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan, P.R. China.ORCID 0000-0003-3011-3359
Shi ChangDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMarital status has emerged as an important influence on several cancer outcomes, but its role in medullary thyroid cancer (MTC) remains unclear. This study was to explore the effects of marital status on the prognosis of MTC patients and to determine whether its effects vary by age. PATIENTS AND

methodsWe retrospectively extracted 1344 eligible patients diagnosed with MTC between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database. Based on the marital status, we divided those patients into married and unmarried groups. We compared the difference in overall survival (OS) and cancer-specific survival (CSS) between married and unmarried via the Kaplan-Meier analysis. Univariate and multivariate Cox proportional models were performed to identify the prognostic factors of OS and CSS.

resultsThere were 1344 MTC eligible patients in a total of which 883 (65.7%) were married and 461 (34.3%) were unmarried. The comparison observed between married and unmarried patients was as follows: male (45.2% vs. 28.0%), age (≥52 years) (55.9% vs. 44.6%), White (86.7% vs. 78.7%), and undergo surgery (97.7% vs. 93.3%). Multivariate analysis revealed unmarried status as a risk factor independently associated with worse OS (HR: 2.15, 95% CI: 1.59-2.92) rate and CSS (HR: 1.70, 95% CI: 1.17-2.47) rate. In a further analysis stratified by age, there was no significant difference in OS and CSS between married and unmarried patients younger than 52 years. For the remaining group with 52 years old and higher, unmarried patients showed significantly higher risk of OS and CSS than married patients at all stages of the pathology except M1 stage.

conclusionMarried patients with MTC have a better prognosis than unmarried ones. Age can affect the association between marital status and the survival of MTC, and married elders may benefit more than youngers.

Indexed as

Age FactorsCarcinoma, NeuroendocrineFemaleHumansMaleMarital StatusMiddle AgedPrognosisRetrospective StudiesRisk FactorsSurvival AnalysisThyroid Neoplasmscancer prognosismarital statusMTCSEER databasesocial support

Identifiers

PMID34723436
PMCPMC8683521

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.