Evidence map›Paper›PMID 34723283›Full record

ArticleJournal of women's health care and management2021

The Intricate Interactions between Maternal Smoking and Drinking During Pregnancy and Birthweight Z-Scores of Preterm Births.

Lucy T Brink, Daan G Nel, David R Hall, Hein J Odendaal

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of women's health care and management, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. The tragedy of smoking, alcohol, and multiple substance use during pregnancy.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lucy T BrinkDepartment of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.
Daan G NelDepartment of Statistics and Actuarial Science, Stellenbosch University, South Africa.
David R HallDepartment of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.
Hein J OdendaalDepartment of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.
Stellenbosch University · ZA

Funding

Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) NetworkU01HD045935 · NICHD · UNIVERSITY OF SOUTH DAKOTA · PI ELLIOTT, AMY J · 2003 to 2015
$16.9M
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) NetworkU01AA016501 · NIAAA · STELLENBOSCH UNIVERSITY · PI ODENDAAL, HENDRIK JOHANNES · 2006 to 2015
$10.0M
Safe PASSage Study Administrative Supplement - Effects of Overnight Maternal SleeU01HD055154 · NICHD · DM-STAT, INC. · PI DUKES, KIMBERLY A. · 2006 to 2017
$9.7M
Prenatal Alcohol Sudden Infant Death Syndrome/StillbirthU01HD045991 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI KINNEY, HANNAH CHASE · 2003 to 2015
$8.4M
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) NetworkU01HD055155 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIFER, WILLIAM P., MYERS, MICHAEL MORGAN · 2006 to 2015
$7.1M
NIAAA NIH HHS U01 AA016501NICHD NIH HHS U01 HD045935NICHD NIH HHS U01 HD045991NICHD NIH HHS U01 HD055154NICHD NIH HHS U01 HD055155
6 · The paper itself

Abstract

backgroundThe extent to which smoking and drinking in a local community is associated with nutrition and Z-scores of infants from spontaneous preterm deliveries, is uncertain.

aimTo investigate associations of different levels of maternal smoking and drinking in spontaneous preterm birth with infant birthweight Z-scores.

methodsInformation, including gestational age (determined by earliest ultrasound), maternal arm circumference (measured at enrolment), smoking-drinking data (obtained up to 4 occasions), birthweight data (obtained from medical records) and birthweight Z-scores (calculated from INTERGROWTH- 21st study), collected over a period of nine years was used to compare 407 spontaneous preterm births with 3 493 spontaneous term births Analyses of variance, correlations and multiple regression were performed in STATISTICA.

resultsWomen with spontaneous preterm birth, had significantly lower gravidity and smaller arm circumference when compared to women with spontaneous birth at term. Women with spontaneous preterm birth drank more and heavier during pregnancy, and more smoked. Gestational age at birth was significantly longer in heavy-smokers-heavy-drinkers compared to heavy-smokers-no-drinkers (7.1 days) and in no-smokers-heavy-drinkers when compared to no-smokers-no-drinkers (11.2 days). Birthweight was significantly lower in low-smokers-heavy-drinkers when compared to low-smokers-no-drinkers (240g) and in heavy-smokers-low-drinkers when compared to no-smokers-low-drinkers (273g). Birthweight Z-scores were significantly lower in low-smokers-heavy-drinkers when compared to low-smokers-low-drinkers and low-smokers-no-drinkers; and, also significantly lower in heavy-smokers-low-drinkers when compared to low-smokers-low-drinkers and no-smokers-low-drinkers.

conclusionAlcohol aggravates the detrimental effect of smoking on birthweight and birthweight Z-scores but seems to counteract the negative association of smoking with gestational age.

Indexed as

Alcohol drinkingBirthweightBirthweight Z-ScoresCigarette smokingGestational agePregnancySpontaneous preterm birth

Identifiers

PMID34723283
PMCPMC8553154
OpenAlexW3170007783

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.