Evidence map›Paper›PMID 34723237›Full record

ArticleCell reports methods2021

An automated platform for structural analysis of membrane proteins through serial crystallography.

Robert D Healey, Shibom Basu, Anne-Sophie Humm, Cedric Leyrat, Xiaojing Cong, Jérôme Golebiowski, Florine Dupeux, Andrea Pica, Sébastien Granier, José Antonio Márquez

Open access · goldAbstract read
In one paragraph

Article in Cell reports methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Robert D HealeyIGF, University of Montpellier, CNRS, INSERM, 34094 Montpellier, France.
Shibom BasuEuropean Molecular Biology Laboratory, 71 Avenue des Martyrs, 38000 Grenoble, France.
Anne-Sophie HummEuropean Molecular Biology Laboratory, 71 Avenue des Martyrs, 38000 Grenoble, France.
Cedric LeyratIGF, University of Montpellier, CNRS, INSERM, 34094 Montpellier, France.
Xiaojing CongIGF, University of Montpellier, CNRS, INSERM, 34094 Montpellier, France.
Jérôme GolebiowskiInstitute of Chemistry of Nice UMR7272, Université Côte d'Azur, CNRS, 28 Avenue Valrose, 06108 Nice, France.
Florine DupeuxEuropean Molecular Biology Laboratory, 71 Avenue des Martyrs, 38000 Grenoble, France.
Andrea PicaEuropean Molecular Biology Laboratory, 71 Avenue des Martyrs, 38000 Grenoble, France.
Sébastien GranierIGF, University of Montpellier, CNRS, INSERM, 34094 Montpellier, France.
José Antonio MárquezEuropean Molecular Biology Laboratory, 71 Avenue des Martyrs, 38000 Grenoble, France.
Centre National de la Recherche Scientifique · FREuropean Molecular Biology Laboratory · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membrane proteins are central to many pathophysiological processes, yet remain very difficult to analyze structurally. Moreover, high-throughput structure-based drug discovery has not yet been exploited for membrane proteins because of lack of automation. Here, we present a facile and versatile platform for

Indexed as

Membrane ProteinsSmall Molecule LibrariesAutomationCrystallizationCrystallography, X-RayHumansMembrane ProteinsSmall Molecule Librariesautomated crystal harvestingautomationCRIMSCrystalDirectdata managementdrug discoveryhigh throughput ligand screeningLCP crystallizationLIMSSSX

Identifiers

PMID34723237
PMCPMC8545655
OpenAlexW3208568937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.