Evidence map›Paper›PMID 34723054›Full record

ArticleResearch and practice in thrombosis and haemostasis2021

Rivaroxaban in acute venous thromboembolism: UK prescribing experience.

Victoria Speed, Jignesh P Patel, Derek Cooper, Stephen Miller, Lara N Roberts, Raj K Patel, Roopen Arya

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02248610 (Follow-up in Rivaroxaban Patients in Setting of Thromboembolism), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02248610 completednot on this map

Follow-up in Rivaroxaban Patients in Setting of Thromboembolism

Typeobservational_patient_registrySponsorKing's College Hospital NHS TrustRan2014 to 2020Enrolled1,343ConditionsVenous ThromboembolismArmsNon-interventional study
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Rivaroxaban in acute venous thromboembolism: UK prescribing experience.Research and practice in thrombosis and haemostasis · 2021
    Article
  4. Risk of Bleeding Associated With Outpatient Use of Rivaroxaban in VTE Management at a National Referral Hospital in Western Kenya.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Victoria SpeedDepartment of Haematological Medicine King's Thrombosis Centre King's College Hospital NHS Foundation Trust London UK.ORCID https://orcid.org/0000-0001-5064-9375
Jignesh P PatelDepartment of Haematological Medicine King's Thrombosis Centre King's College Hospital NHS Foundation Trust London UK.ORCID https://orcid.org/0000-0003-4197-8294
Derek CooperKing's College London London UK.
Stephen MillerProgeny Europe (Windward Systems Ltd.) Norfolk UK.
Lara N RobertsDepartment of Haematological Medicine King's Thrombosis Centre King's College Hospital NHS Foundation Trust London UK.ORCID https://orcid.org/0000-0003-3871-8491
Raj K PatelDepartment of Haematological Medicine King's Thrombosis Centre King's College Hospital NHS Foundation Trust London UK.
Roopen AryaDepartment of Haematological Medicine King's Thrombosis Centre King's College Hospital NHS Foundation Trust London UK.ORCID https://orcid.org/0000-0001-5630-7990
King's College Hospital NHS Foundation Trust · GBKing's College London · GBLigand Pharmaceuticals (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRivaroxaban was reported as effective as traditional therapies for the acute treatment of venous thromboembolism (VTE) with fewer major bleeding complications in the seminal Einstein program and is now a recommended option for the treatment of VTE around the world.

objectiveTo report the safety and efficacy of rivaroxaban in daily care for the management of acute VTE in the United Kingdom. PATIENTS/

methodThe FIRST registry is a UK-only, multicenter, noninterventional, observational VTE study (NCT02248610). Consecutive patients diagnosed with acute VTE, managed with rivaroxaban, were recruited and followed for up to 5 years. The primary outcomes were treatment-emergent symptomatic objectively diagnosed recurrent VTE, major and clinically relevant nonmajor bleeding (CRNMB), and all-cause mortality.

resultsA total of 1262 participants were recruited between 2014 and 2018. Participants were heterogeneous, with age range 18 to 95 years, weight 35 to 234 kg, and maximum body mass index 64.4 kg/m

conclusionsRivaroxaban is an effective and safe single drug modality for the treatment of VTE in daily practice in the United Kingdom. Data to determine the optimal anticoagulation therapy for women of childbearing age are needed.

Indexed as

anticoagulantsdirect‐acting oral anticoagulantpulmonary embolismrivaroxabanvenous thromboembolism

Identifiers

PMID34723054
PMCPMC8531140
OpenAlexW3209002152

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.