Evidence map›Paper›PMID 34723023›Full record

ArticleACS omega2021

A pH and Mg

Jiacheng Zhang, Yang Wang, Liqi Wan, Yuan Liu, Jie Yi, Sik Lok Lam, Pei Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiacheng ZhangSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China.
Yang WangSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China.
Liqi WanDepartment of Chemistry, The Chinese University of Hong Kong, Shatin N.T., Hong Kong, China.ORCID https://orcid.org/0000-0003-3663-2678
Yuan LiuSouth China Advanced Institute for Soft Matter Science and Technology, School of Molecular Science and Engineering, South China University of Technology, Guangzhou, Guangdong 510640, China.
Jie YiSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China.
Sik Lok LamDepartment of Chemistry, The Chinese University of Hong Kong, Shatin N.T., Hong Kong, China.ORCID https://orcid.org/0000-0001-5368-706X
Pei GuoSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China.ORCID https://orcid.org/0000-0001-7760-5786

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Minidumbbell (MDB) is a non-B DNA structure of which the thermodynamic stability is sensitive to a chemical environment such as pH, serving as a potential structural motif in constructing DNA-based molecular switches. This work aims to design thermodynamically stable MDB structures bearing 5' and 3'-overhanging deoxyribonucleotides in order to examine the possibility of MDB to be functionalized. Via making use of 5-methylcytosine and adjusting the pH of solution to be acidic, MDBs bearing 1-nucleotide (nt) or 2-nt overhanging residues at the 5' and 3'-ends have been obtained. Based on one of the new MDB sequences, we have designed a molecular switch that could respond to dual inputs of pH and Mg

Identifiers

PMID34723023
PMCPMC8552455

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.