ArticleWellcome open research2021
The international Perinatal Outcomes in the Pandemic (iPOP) study: protocol.
Article in Wellcome open research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Preterm Birth and Perinatal Mortality During the COVID-19 Pandemic Period: A Systematic Review and Meta-Analysis.Journal of paediatrics and child health · 2026Pooled it
- Impact of COVID-19 pandemic on retinopathy of prematurity services in low resource settings.Eye (London, England) · 2024Article
- Reduction in spontaneous and iatrogenic preterm births in twin pregnancies during COVID-19 lockdown in Melbourne, Australia: a multicenter cohort study.BMC pregnancy and childbirth · 2023Article
- Before the first breath: why ambient air pollution and climate change should matter to neonatal-perinatal providers.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Changes in birth outcomes and utilization of prenatal care during the COVID-19 pandemic in 2020: a secondary analysis of vital statistics in Colombia.BMC pediatrics · 2023Article
- Changes in preterm birth and stillbirth during COVID-19 lockdowns in 26 countries.Nature human behaviour · 2023Article
- Data-enabled responses to pandemics: policy lessons from COVID-19.Nature medicine · 2022Article
- Data capture and sharing in the COVID-19 pandemic: a cause for concern.The Lancet. Digital health · 2022Review
- Increase in preterm stillbirths in association with reduction in iatrogenic preterm births during COVID-19 lockdown in Australia: a multicenter cohort study.American journal of obstetrics and gynecology · 2022Article
- Pregnancy and the SARS-CoV-2 pandemic.Physiological reviews · 2022Article
- Observational
- Data-driven risk stratification for preterm birth in Brazil: a population-based study to develop of a machine learning risk assessment approach.Lancet regional health. Americas · 2021Article
- Changes in obstetric interventions and preterm birth during COVID-19: A nationwide study from Iceland.Acta obstetricia et gynecologica Scandinavica · 2021Article
- Pandemic upheaval offers a huge natural experiment.Nature · 2021Article
- COVID-19 and maternal and perinatal outcomes.The Lancet. Global health · 2021Article
Corrections and comments
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Authors and funding
50 authors at 20 institutions in 16 countries.
Funding
Abstract
Preterm birth is the leading cause of infant death worldwide, but the causes of preterm birth are largely unknown. During the early COVID-19 lockdowns, dramatic reductions in preterm birth were reported; however, these trends may be offset by increases in stillbirth rates. It is important to study these trends globally as the pandemic continues, and to understand the underlying cause(s). Lockdowns have dramatically impacted maternal workload, access to healthcare, hygiene practices, and air pollution - all of which could impact perinatal outcomes and might affect pregnant women differently in different regions of the world. In the international Perinatal Outcomes in the Pandemic (iPOP) Study, we will seize the unique opportunity offered by the COVID-19 pandemic to answer urgent questions about perinatal health. In the first two study phases, we will use population-based aggregate data and standardized outcome definitions to: 1) Determine rates of preterm birth, low birth weight, and stillbirth and describe changes during lockdowns; and assess if these changes are consistent globally, or differ by region and income setting, 2) Determine if the magnitude of changes in adverse perinatal outcomes during lockdown are modified by regional differences in COVID-19 infection rates, lockdown stringency, adherence to lockdown measures, air quality, or other social and economic markers, obtained from publicly available datasets. We will undertake an interrupted time series analysis covering births from January 2015 through July 2020. The iPOP Study will involve at least 121 researchers in 37 countries, including obstetricians, neonatologists, epidemiologists, public health researchers, environmental scientists, and policymakers. We will leverage the most disruptive and widespread "natural experiment" of our lifetime to make rapid discoveries about preterm birth. Whether the COVID-19 pandemic is worsening or unexpectedly improving perinatal outcomes, our research will provide critical new information to shape prenatal care strategies throughout (and well beyond) the pandemic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.