Evidence map›Paper›PMID 34722818›Full record

ArticleBio-protocol2021

Analysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice.

Nick van Gastel, Jessica B Spinelli, Marcia C Haigis, David T Scadden

Open access · greenAbstract read
In one paragraph

Article in Bio-protocol, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Nick van Gastelde Duve Institute, Brussels, Belgium.
Jessica B SpinelliDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Marcia C HaigisDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
David T ScaddenDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
Boston VA Research Institute · USHarvard University · USMassachusetts General Hospital · US

Funding

Metabolic Recycling and Compartmentalization in Tumor ProgressionK00CA234839 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI SPINELLI, JESSICA BROOKE · 2019 to 2022
$394k
NCI NIH HHS K00 CA234839
6 · The paper itself

Abstract

Once thought to be a mere consequence of the state of a cell, intermediary metabolism is now recognized as a key regulator of mammalian cell fate and function. In addition, cell metabolism is often disturbed in malignancies such as cancer, and targeting metabolic pathways can provide new therapeutic options. Cell metabolism is mostly studied in cell cultures

Indexed as

Cancer biologyCell metabolismGlutamineLeukemiaMetabolic tracingMouse models

Identifiers

PMID34722818
PMCPMC8517646
OpenAlexW3204634321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.