ArticleFrontiers in veterinary science2021
Transcriptomic Analysis of STAT1/3 in the Goat Endometrium During Embryo Implantation.
Article in Frontiers in veterinary science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Multi-tissue transcriptomic characterization of endogenous retrovirus-derived transcripts inFrontiers in genetics · 2025Article
- Pregnancy influences expression of interferon-stimulated genes, progesterone receptor and progesterone-induced blocking factor in ovine thyroid.Animal bioscience · 2024Article
- Transcriptomic Analysis of the Developing Testis and Spermatogenesis in Qianbei Ma Goats.Genes · 2023Article
- MSX1 Regulates Goat Endometrial Function by Altering the Plasma Membrane Transformation of Endometrial Epithelium Cells during Early Pregnancy.International journal of molecular sciences · 2023Article
- Integrating Analysis to Identify Differential circRNAs Involved in Goat Endometrial Receptivity.International journal of molecular sciences · 2023Article
- Screening genes related to embryo implantation in Dazu black goats (Capra Hircus) by morphological and transcriptome analyses.Journal of animal science · 2023Article
- YPEL3 Negatively Regulates Endometrial Function via the Wnt/β-Catenin Pathways during Early Pregnancy in Goats.Animals : an open access journal from MDPI · 2022Article
- NF-κB-Dependent Snail Expression Promotes Epithelial-Mesenchymal Transition in Mastitis.Animals : an open access journal from MDPI · 2021Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interferon tau (IFNT), a pregnancy recognition signal in ruminants, promotes the establishment of embryo implantation by inducing the expression of interferon-stimulated genes (ISGs) via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway. However, the precise regulatory mechanism of IFNT in goat embryo implantation remains largely unknown. In this study, we performed RNA sequencing of goat endometrial epithelial cells (gEECs) with or without 20 ng/mL IFNT treatment. Differential comparison showed that there were 442 upregulated differentially expressed genes (DEGs) and 510 downregulated DEGs. Bioinformatic analyses revealed that DEGs were significantly enriched in immune-related functions or pathways. The qRT-PCR validation results showed that the expression levels of STAT family members (STAT1, STAT2, and STAT3) were significantly upregulated in gEECs after IFNT treatment, which is in agreement with the RNA-seq data. Meanwhile, the protein levels of p-STAT1 and p-STAT3 increased significantly in gEECs after 6 and 24 h of IFNT treatment, respectively. Further
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