Evidence map›Paper›PMID 34722588›Full record

ReviewFrontiers in medicine2021

Gene Therapy in Inherited Retinal Diseases: An Update on Current State of the Art.

Alessia Amato, Alessandro Arrigo, Emanuela Aragona, Maria Pia Manitto, Andrea Saladino, Francesco Bandello, Maurizio Battaglia Parodi

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Ciliary Defects in Inherited Retinal Diseases.Advanced genetics (Hoboken, N.J.) · 2026
    Review
  7. Artificial intelligence applications in inherited retinal dystrophies.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  8. Gene Therapy Strategies for the Treatment of Bestrophinopathies.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Review
  11. Rekindling Vision: Innovative Strategies for Treating Retinal Degeneration.International journal of molecular sciences · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Alessia AmatoDepartment of Ophthalmology, Scientific Institute San Raffaele Hospital, Milan, Italy.
Alessandro ArrigoDepartment of Ophthalmology, Scientific Institute San Raffaele Hospital, Milan, Italy.
Emanuela AragonaDepartment of Ophthalmology, Scientific Institute San Raffaele Hospital, Milan, Italy.
Maria Pia ManittoDepartment of Ophthalmology, Scientific Institute San Raffaele Hospital, Milan, Italy.
Andrea SaladinoDepartment of Ophthalmology, Scientific Institute San Raffaele Hospital, Milan, Italy.
Francesco BandelloDepartment of Ophthalmology, Scientific Institute San Raffaele Hospital, Milan, Italy.
Maurizio Battaglia ParodiDepartment of Ophthalmology, Scientific Institute San Raffaele Hospital, Milan, Italy.
San Raffaele University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

choroideremiagene therapyinherited retinal dystrophiesretinitis pigmentosaStargardt diseaseX-linked retinoschisis

Identifiers

PMID34722588
PMCPMC8553993
OpenAlexW3207039831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.