Evidence map›Paper›PMID 34722542›Full record

ReviewFrontiers in cell and developmental biology2021

Subcellular Specialization of Mitochondrial Form and Function in Skeletal Muscle Cells.

T Bradley Willingham, Peter T Ajayi, Brian Glancy

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Sustained loss ofbioRxiv : the preprint server for biology · 2026
    Article
  2. The two faces of mitochondrial CaJournal of physiology and biochemistry · 2026
    Review
  3. In vivo quantification of mitochondrial OThe Journal of physiology · 2026
    Article
  4. A Distinct Population of Mitochondrial miRNA in Human Male Skeletal Muscle Assessed Before and After Exercise.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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  9. Article
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  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Traumatic Skeletal Muscle Injury and Recovery.Advances in experimental medicine and biology · 2025
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

T Bradley WillinghamNational Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Peter T AjayiNational Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Brian GlancyNational Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Across different cell types and within single cells, mitochondria are heterogeneous in form and function. In skeletal muscle cells, morphologically and functionally distinct subpopulations of mitochondria have been identified, but the mechanisms by which the subcellular specialization of mitochondria contributes to energy homeostasis in working muscles remains unclear. Here, we discuss the current data regarding mitochondrial heterogeneity in skeletal muscle cells and highlight potential new lines of inquiry that have emerged due to advancements in cellular imaging technologies.

Indexed as

bioenergeticsintermyofibrillar mitochondriamitochondrial connectivitymitochondrial respirationorganelle interactionsparanuclear mitochondriaparavascular mitochondriasubsarcolemmal mitochondria

Identifiers

PMID34722542
PMCPMC8554132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.