Evidence map›Paper›PMID 34722332›Full record

ArticleFrontiers in cellular and infection microbiology2021

Tuo Chen, Rong Wang, Zhenglan Duan, Xiaomin Yuan, Yang Ding, Zeyu Feng, Fan Bu, Li Liu, Qiong Wang, Jinyong Zhou and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 4 pooled it
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. The Impact ofCurrent neuropharmacology · 2025
    Pooled it
  3. Pooled it
  4. Probiotics for the treatment of depression and its comorbidities: A systemic review.Frontiers in cellular and infection microbiology · 2023
    Pooled it
  5. Trial
  6. Antioxidants (Basel, Switzerland) · 2026
    Article
  7. Unveiling the Molecular Repertoire ofJournal of microbiology and biotechnology · 2026
    Review
  8. Review
  9. Effects of Melatonin andAntioxidants (Basel, Switzerland) · 2026
    Article
  10. mSystems · 2026
    Article
  11. Article
  12. Article
  13. Mechanism and application ofFrontiers in cellular and infection microbiology · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Tuo ChenDepartment of General Surgery, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Rong WangDepartment of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Zhenglan DuanDepartment of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Xiaomin YuanDepartment of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Yang DingDepartment of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Zeyu FengDepartment of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Fan BuDepartment of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Li LiuGlycomics and Glycan Bioengineering Research Center, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, China.
Qiong WangBasic Pharmacology Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Jinyong ZhouCentral Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Lei ZhuCollaborative Innovation Center for Cancer Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Qing NiDepartment of General Surgery, Affiliated Hospital of Yangzhou University, Yangzhou, China.
Guoping ShiCollaborative Innovation Center for Cancer Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Yugen ChenDepartment of Colorectal Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Nanjing University of Chinese Medicine · CNYangzhou University · CNNanjing Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psychological disorders are associated with increased risk of severe inflammatory bowel disease (IBD) by causing gut microbiota dysbiosis and colonic mucosal barrier damage. However, the interaction between chronic restraint stress (CRS), gut microbiota composition, and colonic mucus remains unclear. We demonstrated that mice under CRS conditions exhibited alterations in microbiota composition, disruption of colonic mucus, and aggravation of colitis. In addition, the abundance of

Indexed as

ColitisGastrointestinal MicrobiomeAkkermansiaAnimalsHumansMiceVerrucomicrobiaAkkermansia muciniphilachronic restraint stresscolitiscolonic mucusfecal microbiota transplantation

Identifiers

PMID34722332
PMCPMC8551916
OpenAlexW3205516467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.