Evidence map›Paper›PMID 34722331›Full record

ArticleFrontiers in cellular and infection microbiology2021

Antimicrobial Mechanisms of Leucocyte- and Platelet Rich Fibrin Exudate Against Planktonic

Fabio Rodríguez Sánchez, Tim Verspecht, Ana B Castro, Martine Pauwels, Carlos Rodríguez Andrés, Marc Quirynen, Wim Teughels

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07293962 (Liquid S-Platelet Rich Fibrin as a Potential Adjunct in Conservative Closed Periodontal Debridement for Periodontitis Stages II-IV), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07293962 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Liquid S-Platelet Rich Fibrin as a Potential Adjunct in Conservative Closed Periodontal Debridement for Periodontitis Stages II-IV: A Randomized, Split-mouth, 3-month Clinical Trial

TypeinterventionalSponsorMahsa UniversityRan2024 to 2026Enrolled14ConditionsPeriodontitis Stage II, Periodontitis Stage III, Periodontitis (Stage 3), PeriodontitisArmsNormal saline irrigation, Platelet rich fibrin
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. L-PRF in extra-oral wound care.Periodontology 2000 · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Antimicrobial effect againstJournal of oral biology and craniofacial research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Fabio Rodríguez SánchezDepartment of Oral Health Sciences, Section Periodontology, Catholic University of Leuven and University Hospitals Leuven, Leuven, Belgium.
Tim VerspechtDepartment of Oral Health Sciences, Section Periodontology, Catholic University of Leuven and University Hospitals Leuven, Leuven, Belgium.
Ana B CastroDepartment of Oral Health Sciences, Section Periodontology, Catholic University of Leuven and University Hospitals Leuven, Leuven, Belgium.
Martine PauwelsDepartment of Oral Health Sciences, Section Periodontology, Catholic University of Leuven and University Hospitals Leuven, Leuven, Belgium.
Carlos Rodríguez AndrésDepartment of Preventive Medicine and Public Health, University of the Basque Country, Bilbao, Spain.
Marc QuirynenDepartment of Oral Health Sciences, Section Periodontology, Catholic University of Leuven and University Hospitals Leuven, Leuven, Belgium.
Wim TeughelsDepartment of Oral Health Sciences, Section Periodontology, Catholic University of Leuven and University Hospitals Leuven, Leuven, Belgium.
KU Leuven · BEUniversity of the Basque Country · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leucocyte- and platelet rich fibrin (L-PRF) is an autologous biomaterial used in regenerative procedures. It has an antimicrobial activity against

Indexed as

Anti-Infective AgentsPlatelet-Rich FibrinBiofilmsExudates and TransudatesPilot ProjectsPlanktonPorphyromonas gingivalisAnti-Infective Agentsantimicrobial mechanism of actionbiofilmsinfection diseaseL-PRForal microbiotawound healing

Identifiers

PMID34722331
PMCPMC8548765
OpenAlexW3207371111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.