Evidence map›Paper›PMID 34722316›Full record

ArticleFrontiers in oncology2021

Inhibition of Bromodomain and Extra Terminal (BET) Domain Activity Modulates the IL-23R/IL-17 Axis and Suppresses Acute Graft-

Katiri J Snyder, Hannah K Choe, Yandi Gao, Natalie E Sell, Kara M Braunreiter, Nina C Zitzer, Lotus Neidemire-Colley, Sonu Kalyan, Adrienne M Dorrance, Andrea Keller and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  5. Review
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  7. Super enhancer lncRNAs: a novel hallmark in cancer.Cell communication and signaling : CCS · 2024
    Review
  8. Review
  9. Review
  10. Article
  11. Cell transplantation
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Katiri J SnyderDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
Hannah K ChoeDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
Yandi GaoDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
Natalie E SellDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
Kara M BraunreiterDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
Nina C ZitzerDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
Lotus Neidemire-ColleyDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
Sonu KalyanDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
Adrienne M DorranceDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
Andrea KellerDepartment of Biological Chemistry and Pharmacology, Comprehensive Cancer Center, The Ohio State University Columbus, Columbus, OH, United States.
Maria M MihaylovaDepartment of Biological Chemistry and Pharmacology, Comprehensive Cancer Center, The Ohio State University Columbus, Columbus, OH, United States.
Satishkumar SinghDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
Lalit SehgalDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
Gideon BollagPlexxikon Inc, South San Francisco, CA, United States.
Yan MaPlexxikon Inc, South San Francisco, CA, United States.
Ben PowellPlexxikon Inc, South San Francisco, CA, United States.
Steven M DevineDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
Parvathi RanganathanDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, United States.
The Ohio State University · USPlexxikon (United States)

Funding

Targeting epigenetic regulation via Bromodomain and Extraterminal (BET) domain inhibition for treatment of GVHDR01CA252469 · NCI · OHIO STATE UNIVERSITY · PI CHOE, HANNAH, RANGANATHAN, PARVATHI · 2021 to 2025
$2.0M
Cellular, molecular, and biochemical sciences training grantT32GM086252 · NIGMS · OHIO STATE UNIVERSITY · PI JACKMAN, JANE ELIZABETH, MUSIER-FORSYTH, KARIN M · 2011 to 2020
$2.0M
Understanding the Mechanisms of Age-Dependent Decline of Intestinal Stem Cell FunctionR00AG054760 · NIA · OHIO STATE UNIVERSITY · PI MIHAYLOVA, MARIA M. · 2018 to 2020
$747k
NCI NIH HHS R01 CA252469NIA NIH HHS R00 AG054760NIGMS NIH HHS T32 GM086252
6 · The paper itself

Abstract

Acute graft-

Indexed as

BET (Bromodomain and extra-terminal) inhibitorGVHDGVHD biologyIL-23RT cells

Identifiers

PMID34722316
PMCPMC8554203
OpenAlexW3206266031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.