ArticleProceedings of the National Academy of Sciences of the United States of America1987
Gamma-actin: unusual mRNA 3'-untranslated sequence conservation and amino acid substitutions that may be cancer related.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 40 citations in OpenAlex.
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- Identification of candidate cancer genes involved in human retinoblastoma by data mining.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2008Article
- Analysis of differentially expressed proteins in cancerous and normal colonic tissues.World journal of gastroenterology · 2006Article
- Intracellular localization and biochemical function of variant beta-actin, which inhibits metastasis of B16 melanoma.Japanese journal of cancer research : Gann · 1994Article
- Effect of myogenic and adipogenic differentiation on expression of colony-stimulating factor genes.Molecular and cellular biology · 1990Article
- Diverse soybean actin transcripts contain a large intron in the 5' untranslated leader: structural similarity to vertebrate muscle actin genes.Plant molecular biology · 1990Article
- Differential requirements of gag and gamma-actin domains for transforming potential of Gardner-Rasheed feline sarcoma virus.Journal of virology · 1989Article
- Differential expression of glial fibrillary acidic protein in human glioma cell lines.Acta neuropathologica · 1989Article
- Interactions between coronavirus nucleocapsid protein and viral RNAs: implications for viral transcription.Journal of virology · 1988Article
- Isolation of cDNA clones for mouse cytoskeletal gamma-actin and differential expression of cytoskeletal actin mRNAs in mouse cells.Molecular and cellular biology · 1988Article
- Cell-cycle-specific and serum-dependent expression of gamma-actin mRNA in Swiss mouse 3T3 cells.Molecular and cellular biology · 1988Article
- Isolation of cDNAs encoding desmosomal plaque proteins: evidence that bovine desmoplakins I and II are derived from two mRNAs and a single gene.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
beta-Actin mutations in chemically transformed human cell lines have been associated with tumorigenicity, an association consistent with other evidence suggesting that altered cytoskeletal proteins may have an important role in cancer initiation or progression. From a human promyelocytic leukemia cell line, we have isolated a gamma-actin cDNA clone with amino acid substitutions in a region highly conserved in the many actins analyzed. To our knowledge, this is the first example of a variant gamma-actin in a human neoplasm. A separate finding from the analysis of this clone is that the gamma-actin 3'-untranslated region is among the most highly conserved of all 3'-untranslated sequences so far reported, but is entirely different from the beta-actin 3'-untranslated region. The high degree of evolutionary conservation suggests that the 3'-untranslated regions of these two mRNAs have important and distinct functional roles that were already fully differentiated more than 100 million years ago. Mutations affecting four major cytoskeletal components have now been identified in human neoplastic cells. These findings suggest that mutated cytoskeletal genes may be members of a class of oncogenes, fundamentally different from both the nuclear-acting (e.g., myc and simian virus 40 large tumor antigen) and growth factor/receptor/protein kinase-related (e.g., sis, erbB, and ras) types of oncogenes.
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