ReviewCureus2021
Correlation Between High Serum Ferritin Level and Gestational Diabetes: A Systematic Review.
Review in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Association of iron nutritional homeostasis and hepcidin gene polymorphisms with gestational diabetes mellitus.BMC pregnancy and childbirth · 2026Article
- The association between serum ferritin levels and the risk of gestational diabetes mellitus: a prospective cohort study.BMC pregnancy and childbirth · 2025Article
- Monochorionic-specific association between first-trimester serum ferritin and gestational diabetes in twin pregnancies: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Article
- The Role of Maternal Serum Ferritin in Gestational Diabetes Mellitus in Southeast Asia.Cureus · 2024Article
- Association of mid-pregnancy ferritin levels with postpartum glucose metabolism in women with gestational diabetes.Nutrition & diabetes · 2024Article
- Article
- Scientific opinion on the tolerable upper intake level for iron.EFSA journal. European Food Safety Authority · 2024Article
- Ferritin and iron supplements in gestational diabetes mellitus: less or more?European journal of nutrition · 2024Review
- Article
- Glycated CD59 is a potential biomarker for gestational diabetes mellitus.Frontiers in endocrinology · 2024Article
- Mitochondria-associated programmed cell death as a therapeutic target for age-related disease.Experimental & molecular medicine · 2023Review
- Incident type 2 diabetes attributable to suboptimal diet in 184 countries.Nature medicine · 2023Article
- Construction and validation of risk prediction model for gestational diabetes based on a nomogram.American journal of translational research · 2023Article
- Maternal hemoglobin change from early pregnancy to second trimester is associated with risk of gestational diabetes mellitus: a retrospective cohort study.Frontiers in nutrition · 2023Article
- Association of gestational hypertriglyceridemia, diabetes with serum ferritin levels in early pregnancy: a retrospective cohort study.Frontiers in endocrinology · 2023Article
- Iron Supplementation in Pregnancy and Risk of Gestational Diabetes: A Narrative Review.Nutrients · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gestational diabetes mellitus (GDM) is a growing pregnancy-related health problem all over the world. It has been noticed that women with high serum ferritin levels have a strong relationship with GDM by increased insulin resistance and increased insulin secretion from the pancreas resulting in pancreatic beta-cell exhaustion. Heme iron is also responsible for increasing the body's iron store and hence causing oxidative injury to pancreatic cells. In this systematic review, we researched the association between high serum ferritin levels and GDM. Three databases were consulted for articles related to GDM and high ferritin. These include Medical Literature Analysis and Retrieval System Online (MEDLINE), PubMed, and PubMed Central (PMC). Additional articles were retrieved from the institutional database. After filtering, 10 articles were finally selected, and quality was checked using the Joanna Briggs Institute (JBI) Critical Appraisal quality check tool. Serum iron biomarkers including ferritin, iron, and soluble transferrin receptor (sTfR) were measured. Our systematic review indicates that high maternal serum ferritin has a significant role in the development of GDM. We have also noticed the importance of sTfR and serum hepcidin as biomarkers to monitor high ferritin levels. Our study also observed a positive relationship between high heme iron intake and gestational diabetes mellitus. Therefore, more research is required to understand this relationship to identify populations at risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.