Evidence map›Paper›PMID 34721757›Full record

ArticleOxidative medicine and cellular longevity2021

Oridonin Alters Hepatic Urea Cycle via Gut Microbiota and Protects against Acetaminophen-Induced Liver Injury.

Mu-Keng Hong, Hai-Hua Liu, Gui-Hong Chen, Jun-Qing Zhu, Song-Yuan Zheng, Di Zhao, Jianxing Diao, Hui Jia, Ding-Ding Zhang, Shi-Xian Chen and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Canadian journal of gastroenterology & hepatology · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Germinated Millet (International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Mu-Keng HongDepartment of Rheumatic & TCM Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Hai-Hua LiuDepartment of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Gui-Hong ChenDepartment of Traditional Chinese Internal Medicine, School of Traditional Chinese Medical, Southern Medical University, Guangzhou, China.
Jun-Qing ZhuDepartment of Rheumatic & TCM Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Song-Yuan ZhengDepartment of Rheumatic & TCM Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Di ZhaoDepartment of Traditional Chinese Internal Medicine, School of Traditional Chinese Medical, Southern Medical University, Guangzhou, China.
Jianxing DiaoDepartment of Traditional Chinese Internal Medicine, School of Traditional Chinese Medical, Southern Medical University, Guangzhou, China.
Hui JiaDepartment of Traditional Chinese Internal Medicine, School of Traditional Chinese Medical, Southern Medical University, Guangzhou, China.
Ding-Ding ZhangDepartment of Traditional Chinese Internal Medicine, School of Traditional Chinese Medical, Southern Medical University, Guangzhou, China.
Shi-Xian ChenDepartment of Rheumatic & TCM Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-7200-433X
Lei GaoDepartment of Traditional Chinese Internal Medicine, School of Traditional Chinese Medical, Southern Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-2705-1989
Juan LiDepartment of Rheumatic & TCM Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-2977-2966
Nanfang Hospital · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetaminophen (APAP) hepatotoxicity is the leading cause of acute liver failure in the western world. Oridonin (OD), which is the major active ingredient of the traditional Chinese medicine

Indexed as

AcetaminophenAnimalsBacteroidesChemical and Drug Induced Liver InjuryDisease Models, AnimalDiterpenes, KauraneDysbiosisFecal Microbiota TransplantationGastrointestinal MicrobiomeLiverMaleMetabolomeMiceMice, Inbred C57BLMice, KnockoutNF-E2-Related Factor 2AcetaminophenDiterpenes, KauraneNfe2l2 protein, mouseNF-E2-Related Factor 2oridoninUrea

Identifiers

PMID34721757
PMCPMC8553473
OpenAlexW3205308979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.