Evidence map›Paper›PMID 34721751›Full record

ArticleJournal of medical devices2021

Apparatus for In Vivo Knee Laxity Assessment Using High-Speed Stereo Radiography.

Thor E Andreassen, Landon D Hamilton, Donald Hume, Sean E Higinbotham, Yashar Behnam, Chadd Clary, Kevin B Shelburne

Abstract read
In one paragraph

Article in Journal of medical devices, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. A scoping review and guide for in vitro healthy human knee joint laxity.Frontiers in bioengineering and biotechnology · 2026
    Review
  2. Article
  3. Validating subject-specific knee models fromFrontiers in bioengineering and biotechnology · 2025
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thor E AndreassenDepartment of Mechanical and Materials Engineering, The University of Denver, 2155 E. Wesley Ave., Denver, CO 80210.
Landon D HamiltonDepartment of Mechanical and Materials Engineering, The University of Denver, 2155 E. Wesley Ave., Denver, CO 80210.
Donald HumeDepartment of Mechanical and Materials Engineering, The University of Denver, 2155 E. Wesley Ave., Denver, CO 80210.
Sean E HiginbothamDepartment of Mechanical and Materials Engineering, The University of Denver, 2155 E. Wesley Ave., Denver, CO 80210.
Yashar BehnamDepartment of Mechanical and Materials Engineering, The University of Denver, 2155 E. Wesley Ave., Denver, CO 80210.
Chadd ClaryDepartment of Mechanical and Materials Engineering, The University of Denver, 2155 E. Wesley Ave., Denver, CO 80210.
Kevin B ShelburneDepartment of Mechanical and Materials Engineering, The University of Denver, 2155 E. Wesley Ave., Denver, CO 80210.

Funding

A Lower Extremity Neuromusculoskeletal Human Simulator: Addressing Multiscale ChallengesU01AR072989 · NIAMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI SHELBURNE, KEVIN B · 2018 to 2021
$1.9M
NIAMS NIH HHS U01 AR072989
6 · The paper itself

Abstract

Computational modeling is of growing importance in orthopedics and biomechanics as a tool to understand differences in pathology and predict outcomes from surgical interventions. However, the computational models of the knee have historically relied on in vitro data to create and calibrate model material properties due to the unavailability of accurate in vivo data. This work demonstrates the design and use of a custom device to quantify anterior-posterior (AP) and internal-external (IE) in vivo knee laxity, with an accuracy similar to existing in vitro methods. The device uses high-speed stereo radiography (HSSR) tracking techniques to accurately measure the resulting displacements of the femur, tibia, and patella bones during knee laxity assessment at multiple loads and knee flexion angles. The accuracy of the knee laxity apparatus was determined by comparing laxity data from two cadaveric specimens between the knee laxity apparatus and an existing in vitro robotic knee joint simulator. The accuracy of the knee laxity apparatus was within 1 mm (0.04 in.) for AP and 2.5 deg for IE. Additionally, two living subjects completed knee laxity testing to confirm the laboratory use of the novel apparatus. This work demonstrates the ability to use custom devices in HSSR to collect accurate data, in vivo, for calibration of computational models.

Identifiers

PMID34721751
PMCPMC8546959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.