Evidence map›Paper›PMID 34721500›Full record

ArticleDementia and geriatric cognitive disorders extra

Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period.

Hediyeh Baradaran, Alen Delic, J Scott McNally, Matthew Alexander, Jennifer J Majersik, Dennis L Parker, Adam de Havenon

Open access · goldAbstract read
In one paragraph

Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hediyeh BaradaranDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, USA.
Alen DelicDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
J Scott McNallyDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, USA.
Matthew AlexanderDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, USA.
Jennifer J MajersikDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
Dennis L ParkerDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, USA.
Adam de HavenonDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
University of Utah · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Improved imaging of carotid plaque using high-resolution, motion-corrected 3D MRIR01HL127582 · NHLBI · UNIVERSITY OF UTAH · PI PARKER, DENNIS L · 2016 to 2019
$2.3M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL127582
6 · The paper itself

Abstract

introductionWe evaluated the association between carotid compliance, a measure of arterial stiffness, to parahippocampal volume (PHV) and hippocampal volume (HV) over 20 years later in the Atherosclerosis Risk in the Community study.

methodsWe included participants with common carotid compliance measurements at visit 1 (1987-1989) and volumetric brain MRI at visit 5 (2011-2013). The primary outcomes are pooled bilateral PHV and HV. We performed linear regression models adjusting for age, sex, vascular risk factors, and total brain volume.

resultsOf the 614 participants, higher compliance was correlated with higher PHV (

conclusionCarotid compliance is associated with higher PHV and HV when measured 20 years later, further supporting the link between arterial stiffness and cognitive decline.

Indexed as

Brain imagingCerebrovascular diseasesVascular causes of cognitive impairment

Identifiers

PMID34721500
PMCPMC8543351
OpenAlexW3200385446

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.