Evidence map›Paper›PMID 34721414›Full record

Trial reportFrontiers in immunology2021

Dexamethasone-Induced FKBP51 Expression in CD4

Vickram Tejwani, Amanda McCormack, Karthik Suresh, Han Woo, Ningchun Xu, Meghan F Davis, Emily Brigham, Nadia N Hansel, Meredith C McCormack, Franco R D'Alessio

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Comparative response to pharmacological management of asthma in overweight/obese childrenEuropean respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Trial
  3. A Combined Bioinformatics and Clinical Validation Study IdentifiesInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Distinct single-cell transcriptional profile in CD4+ T-lymphocytes among obese children with asthma.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Vickram TejwaniJohns Hopkins University, Division of Pulmonary and Critical Care Medicine, Baltimore, MD, United States.
Amanda McCormackDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Karthik SureshJohns Hopkins University, Division of Pulmonary and Critical Care Medicine, Baltimore, MD, United States.
Han WooJohns Hopkins University, Division of Pulmonary and Critical Care Medicine, Baltimore, MD, United States.
Ningchun XuFlow Cytometry Core, Johns Hopkins University, Baltimore, MD, United States.
Meghan F DavisDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Emily BrighamJohns Hopkins University, Division of Pulmonary and Critical Care Medicine, Baltimore, MD, United States.
Nadia N HanselJohns Hopkins University, Division of Pulmonary and Critical Care Medicine, Baltimore, MD, United States.
Meredith C McCormackJohns Hopkins University, Division of Pulmonary and Critical Care Medicine, Baltimore, MD, United States.
Franco R D'AlessioJohns Hopkins University, Division of Pulmonary and Critical Care Medicine, Baltimore, MD, United States.
Johns Hopkins University · USCleveland Clinic · US

Funding

MULTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007534 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Nadia N Hansel, Larissa A. Shimoda · 1985 to 2026
$28.3M
Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
The role of obesity in biological responses to particulate matter in miceP50ES018176 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2015 to 2019
$4.8M
Lung Injury Repair by Regulatory T cell LGP2R01HL131812 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI D'ALESSIO, FRANCO RAFAEL · 2017 to 2020
$1.6M
Relationship Between Indoor Ultrafine Particle Exposure and Respiratory Morbidity, Inflammation, and Oxidative Stress in Children with AsthmaK23ES029105 · NIEHS · UNIVERSITY OF BRITISH COLUMBIA · PI BRIGHAM, EMILY · 2019 to 2022
$755k
Effects of pest and pet animal microbiota on child microbiota and asthma: a one health studyK01OD019918 · OD · JOHNS HOPKINS UNIVERSITY · PI DAVIS, MEGHAN F. · 2016 to 2020
$621k
Macrophage phenotype and COPD severityF32HL149258 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TEJWANI, VICKRAM · 2019 to 2020
$145k
NHLBI NIH HHS F32 HL149258NHLBI NIH HHS R01 HL131812NHLBI NIH HHS T32 HL007534NIEHS NIH HHS K23 ES029105NIEHS NIH HHS P50 ES018176NIEHS NIH HHS T32 ES007141NIH HHS K01 OD019918
6 · The paper itself

Abstract

Introduction: There is evidence that obesity, a risk factor for asthma severity and morbidity, has a unique asthma phenotype which is less atopic and less responsive to inhaled corticosteroids (ICS). Peripheral blood mononuclear cells (PBMC) are important to the immunologic pathways of obese asthma and steroid resistance. However, the cellular source associated with steroid resistance has remained elusive. We compared the lymphocyte landscape among obese children with asthma to matched normal weight children with asthma and assessed relationship to asthma control. Methods: High-dimensional flow cytometry of PBMC at baseline and after dexamethasone stimulation was performed to characterize lymphocyte subpopulations, T-lymphocyte polarization, proliferation (Ki-67+), and expression of the steroid-responsive protein FK506-binding protein 51 (FKBP51). T-lymphocyte populations were compared between obese and normal-weight participants, and an unbiased, unsupervised clustering analysis was performed. Differentially expressed clusters were compared with asthma control, adjusted for ICS and exhaled nitric oxide. Results: In the obese population, there was an increased cluster of CD4 Discussion: Dexamethasone-induced CD4

Indexed as

Air FiltersAnti-Inflammatory AgentsAsthmaCD4-Positive T-LymphocytesChildDexamethasoneDrug ResistanceFemaleHumansMaleParticulate MatterPediatric ObesityTacrolimus Binding Protein 5Tacrolimus Binding ProteinsAnti-Inflammatory AgentsDexamethasoneParticulate MatterTacrolimus Binding Protein 5Tacrolimus Binding Proteinsasthmaimmune mechanismobesitysteroid-resistanceT-lymphocytes

Identifiers

PMID34721414
PMCPMC8554235
OpenAlexW3206777648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.