Evidence map›Paper›PMID 34721393›Full record

ArticleFrontiers in immunology2021

Two Distinct Lysosomal Targeting Strategies Afford Trojan Horse Antibodies With Pan-Filovirus Activity.

Ariel S Wirchnianski, Anna Z Wec, Elisabeth K Nyakatura, Andrew S Herbert, Megan M Slough, Ana I Kuehne, Eva Mittler, Rohit K Jangra, Jonathan Teruya, John M Dye and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Outsmarting Pathogens with Antibody Engineering.Annual review of chemical and biomolecular engineering · 2023
    Review
  7. Exosomal transmission of viruses, a two-edged biological sword.Cell communication and signaling : CCS · 2023
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ariel S WirchnianskiDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United States.
Anna Z WecDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United States.
Elisabeth K NyakaturaDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, United States.
Andrew S HerbertVirology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States.
Megan M SloughDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United States.
Ana I KuehneVirology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States.
Eva MittlerDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United States.
Rohit K JangraDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United States.
Jonathan TeruyaAntibody Discovery and Research group, Mapp Biopharmaceutical, San Diego, CA, United States.
John M DyeVirology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, United States.
Jonathan R LaiDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, United States.
Kartik ChandranDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United States.
Albert Einstein College of Medicine · USUnited States Army Medical Research Institute of Infectious Diseases · USMapp Biopharmaceutical (United States) · US

Funding

A "Trojan Horse" bispecific antibody strategy for broad filovirus therapeuticsR01AI132256 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHANDRAN, KARTIK, LAI, JONATHAN R. · 2017 to 2021
$6.1M
Geographic Medicine and Emerging InfectionsT32AI070117 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2008 to 2023
$5.1M
Engineered, multispecific antibodies as broad anti-filovirus therapeuticsR01AI125462 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI LAI, JONATHAN R. · 2017 to 2020
$3.0M
Host-virus interactions in the control of filovirus entryR01AI134824 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHANDRAN, KARTIK · 2018 to 2021
$1.9M
NIAID NIH HHS R01 AI125462NIAID NIH HHS R01 AI132256NIAID NIH HHS R01 AI134824NIAID NIH HHS T32 AI070117
6 · The paper itself

Abstract

Multiple agents in the family

Indexed as

Antibodies, BispecificAntiviral AgentsBroadly Neutralizing AntibodiesEbolavirusEpitopesHemorrhagic Fever, EbolaHost-Pathogen InteractionsHumansLigandsLysosomesNiemann-Pick C1 ProteinProtein EngineeringReceptor, IGF Type 2THP-1 CellsVesicular Transport ProteinsViral Envelope ProteinsAntibodies, BispecificAntiviral AgentsBroadly Neutralizing Antibodiesenvelope glycoprotein, Ebola virusEpitopesIGF2R protein, humanLigandsNiemann-Pick C1 ProteinNPC1 protein, humanNPC2 protein, humanReceptor, IGF Type 2Vesicular Transport ProteinsViral Envelope Proteinscryptic epitopesEbolafilovirusIGF2MarburgNPC1NPC2Trojan Horse bispecific antibodies

Identifiers

PMID34721393
PMCPMC8551868
OpenAlexW3207228945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.