Evidence map›Paper›PMID 34721386›Full record

ArticleFrontiers in immunology2021

Drug Repurposing for Atopic Dermatitis by Integration of Gene Networking and Genomic Information.

Wirawan Adikusuma, Lalu Muhammad Irham, Wan-Hsuan Chou, Henry Sung-Ching Wong, Eko Mugiyanto, Jafit Ting, Dyah Aryani Perwitasari, Wei-Pin Chang, Wei-Chiao Chang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  5. Integrated genomic network analysis revealed potential of a druggable target for hemorrhoid treatment.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Wirawan AdikusumaDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Lalu Muhammad IrhamDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Wan-Hsuan ChouDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Henry Sung-Ching WongDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Eko MugiyantoPh. D. Program in the Clinical Drug Development of Herbal Medicines, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Jafit TingDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Dyah Aryani PerwitasariFaculty of Pharmacy, University of Ahmad Dahlan, Yogyakarta, Indonesia.
Wei-Pin ChangSchool of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan.
Wei-Chiao ChangDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Taipei Medical University · TWUniversitas Ahmad Dahlan · IDUniversitas Pekalongan · IDWan Fang Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic Dermatitis (AD) is a chronic and relapsing skin disease. The medications for treating AD are still limited, most of them are topical corticosteroid creams or antibiotics. The current study attempted to discover potential AD treatments by integrating a gene network and genomic analytic approaches. Herein, the Single Nucleotide Polymorphism (SNPs) associated with AD were extracted from the GWAS catalog. We identified 70 AD-associated loci, and then 94 AD risk genes were found by extending to proximal SNPs based on

Indexed as

Drug RepositioningGene Regulatory NetworksAnimalsAntibodies, MonoclonalComputational BiologyDermatitis, AtopicGenome-Wide Association StudyGenomicsHumansMiceMice, KnockoutPolymorphism, Single NucleotideProtein Interaction MapsAntibodies, Monoclonalatopic dermatitisbioinformaticsdrug repurposingfunctional annotationgenetic

Identifiers

PMID34721386
PMCPMC8548825
OpenAlexW3206128202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.