Evidence map›Paper›PMID 34721383›Full record

ReviewFrontiers in immunology2021

Regulatory T-Cell Therapy in Liver Transplantation and Chronic Liver Disease.

Angus Hann, Ye H Oo, M Thamara P R Perera

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
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  15. ScRNA-seq revealed disruption in CD8Immunity, inflammation and disease · 2023
    Article
  16. Review
  17. A TNature aging · 2023
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Angus HannThe Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
Ye H OoThe Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
M Thamara P R PereraThe Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The constant exposure of the liver to gut derived foreign antigens has resulted in this organ attaining unique immunological characteristics, however it remains susceptible to immune mediated injury. Our understanding of this type of injury, in both the native and transplanted liver, has improved significantly in recent decades. This includes a greater awareness of the tolerance inducing CD4

Indexed as

Liver TransplantationAnimalsCell Transformation, NeoplasticCellular MicroenvironmentChronic DiseaseDisease ManagementDisease SusceptibilityHumansImmunomodulationImmunotherapyLiver DiseasesT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsTreatment Outcomecell therapycirrhosisimmunityliverrejectiontransplantTreg

Identifiers

PMID34721383
PMCPMC8552037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.