Evidence map›Paper›PMID 34721353›Full record

ArticleFrontiers in microbiology2021

Discovering the Potentials of Four Phage Endolysins to Combat Gram-Negative Infections.

Daria V Vasina, Nataliia P Antonova, Igor V Grigoriev, Victoria S Yakimakha, Anastasiya M Lendel, Maria A Nikiforova, Andrei A Pochtovyi, Timofey A Remizov, Evgeny V Usachev, Natalia V Shevlyagina and 10 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Phage and endolysin-based inhibition ofFrontiers in cellular and infection microbiology · 2026
    Review
  3. Wound-Healing Potential of Engineered Lysin GRC-ML07 inAntibiotics (Basel, Switzerland) · 2025
    Article
  4. Review
  5. CombatingFrontiers in cellular and infection microbiology · 2025
    Review
  6. Comprehensive Approaches to CombattingAntibiotics (Basel, Switzerland) · 2024
    Review
  7. Article
  8. Article
  9. Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Daria V VasinaLaboratory of Pathogen Population Variability Mechanisms, N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Nataliia P AntonovaLaboratory of Pathogen Population Variability Mechanisms, N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Igor V GrigorievTranslational Biomedicine Laboratory, N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Victoria S YakimakhaFaculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
Anastasiya M LendelLaboratory of Pathogen Population Variability Mechanisms, N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Maria A NikiforovaLaboratory of Pathogen Population Variability Mechanisms, N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Andrei A PochtovyiLaboratory of Pathogen Population Variability Mechanisms, N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Timofey A RemizovTranslational Biomedicine Laboratory, N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Evgeny V UsachevLaboratory of Pathogen Population Variability Mechanisms, N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Natalia V ShevlyaginaLaboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Vladimir G ZhukhovitskyLaboratory of Indication and Ultrastructural Analysis of Microorganisms, N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Mikhail V FursovAerobiological Laboratory, State Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia.
Vasiliy D PotapovAerobiological Laboratory, State Research Center for Applied Microbiology and Biotechnology, Obolensk, Russia.
Aleksei M VorobevLaboratory of Clinical Microbiology and Biotechnology of Bacteriophages, G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Moscow, Russia.
Andrey V AleshkinLaboratory of Clinical Microbiology and Biotechnology of Bacteriophages, G. N. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology, Moscow, Russia.
Aleksei I LaishevtsevLaboratory for Diagnostics and Control of Antibiotic Resistance of the Most Clinically Significant Pathogens of Animals, Federal State Budget Scientific Institution "Federal Scientific Centre VIEV" (FSC VIEV), Moscow, Russia.
Valentine V MakarovCenter for Strategic Planning of the Ministry of Health of the Russian Federation, Moscow, Russia.
Sergey M YudinCenter for Strategic Planning of the Ministry of Health of the Russian Federation, Moscow, Russia.
Artem P TkachukTranslational Biomedicine Laboratory, N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Vladimir A GushchinLaboratory of Pathogen Population Variability Mechanisms, N. F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Ministry of Health of the Russian Federation · RUGabrichevsky Institute of Epidemiology and Microbiology · RULomonosov Moscow State University · RUState Research Center for Applied Microbiology and Biotechnology · RUAll-Russian Scientific Research Institute of Experimental Veterinary Sciences. Ya.R. Kovalenko · RUCenter for Strategic Research · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endolysin-based therapeutics are promising antibacterial agents and can successfully supplement the existing antibacterial drugs array. It is specifically important in the case of Gram-negative pathogens, e.g., ESKAPE group bacteria, which includes

Indexed as

animal modelsantimicrobial agentsendolysinGram-negative bacterialocal infectionsafety

Identifiers

PMID34721353
PMCPMC8548769
OpenAlexW3206404992

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.