Evidence map›Paper›PMID 34721291›Full record

SynthesisFrontiers in endocrinology2021

CDK5 Regulatory Subunit-Associated Protein 1-Like 1 Gene Polymorphisms and Gestational Diabetes Mellitus Risk: A Trial Sequential Meta-Analysis of 13,306 Subjects.

Xiang-Yuan Yu, Li-Ping Song, Shu-Dan Wei, Xiao-Lan Wen, Da-Bin Liu

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Research Progress of Risk Factors Associated with Gestational Diabetes Mellitus.Endocrine, metabolic & immune disorders drug targets · 2025
    Review
  5. Review
  6. Article
  7. Association of theBMJ open diabetes research & care · 2023
    Article
  8. Review
  9. Genetic variants ofFrontiers in endocrinology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiang-Yuan YuDepartment of Epidemiology and Health Statistics, Guilin Medical University, Guilin, China.
Li-Ping SongDepartment of Epidemiology and Health Statistics, Guilin Medical University, Guilin, China.
Shu-Dan WeiDepartment of Epidemiology and Health Statistics, Guilin Medical University, Guilin, China.
Xiao-Lan WenDepartment of Epidemiology and Health Statistics, Guilin Medical University, Guilin, China.
Da-Bin LiuFujian Key Laboratory of Women and Children's Critical Diseases Research, Fujian Maternity and Child Health Hospital, Fuzhou, China.
Guilin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The CDK5 regulatory subunit-associated protein 1-like 1 ( Materials and Methods: A meta-analysis with a fixed- or random-effects model was conducted to estimate the correlation between studied Results: A total of 13,306 subjects were included in the present study. Meta-analysis results showed that the variant heterozygous and homozygous genotypes of the two polymorphisms were associated with increased GDM risk in comparison with the wild-type AA genotype (AG Conclusions: This study supported the finding that rs7756992 and rs7754840 are associated with susceptibility to GDM. However, further functional studies are warranted to clarify the mechanism.

Indexed as

Case-Control StudiesCyclin-Dependent Kinase 5Diabetes, GestationalFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotidePregnancyRisk FactorstRNA MethyltransferasesCDK5 protein, humanCDKAL1 protein, humanCyclin-Dependent Kinase 5tRNA Methyltransferasesfalse-positive report probabilitygestational diabetes mellitus (GDM)meta-analysispolymorphismtrial sequential analysis (TSA)

Identifiers

PMID34721291
PMCPMC8551443
OpenAlexW3207359757

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.