ArticleFrontiers in behavioral neuroscience2021
LMT USV Toolbox, a Novel Methodological Approach to Place Mouse Ultrasonic Vocalizations in Their Behavioral Contexts-A Study in Female and Male C57BL/6J Mice and in
Article in Frontiers in behavioral neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- A deep neural network for automatic prediction of mouse behavior from ultrasonic vocalizations emitted during social interaction test.Scientific reports · 2026Article
- Courtship and distress ultrasonic vocalizations are altered in a mouse model of Angelman syndrome.Journal of neurodevelopmental disorders · 2025Article
- Oxytocin signaling regulates maternally directed behavior during early life.Science (New York, N.Y.) · 2025Article
- Incubation of social deficit during morphine abstinence in male mice using a novel unbiased and automatized method.Frontiers in behavioral neuroscience · 2025Article
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- Prenatal treatment with preimplantation factor improves early postnatal neurogenesis and cognitive impairments in a mouse model of Down syndrome.Cellular and molecular life sciences : CMLS · 2024Article
- Detecting Central Auditory Processing Disorders in Awake Mice.Brain sciences · 2023Article
- Rodent ultrasonic vocal interaction resolved with millimeter precision using hybrid beamforming.eLife · 2023Article
- Immune activation during pregnancy exacerbates ASD-related alterations in Shank3-deficient mice.Molecular autism · 2023Article
- Day-to-day spontaneous social behaviours is quantitatively and qualitatively affected in a 16p11.2 deletion mouse model.Frontiers in behavioral neuroscience · 2023Article
- Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum ofFrontiers in molecular neuroscience · 2023Article
- Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents.Molecular autism · 2022Review
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- The Impact of Mouse Preterm Birth Induction by RU-486 on Microglial Activation and Subsequent Hypomyelination.International journal of molecular sciences · 2022Article
- Long-term behavioral effects of prenatal stress in the Fmr1-knock-out mouse model for fragile X syndrome.Frontiers in cellular neuroscience · 2022Article
- From Mating to Milk Access: A Review of Reproductive Vocal Communication in Mice.Frontiers in behavioral neuroscience · 2022Review
- Transient reduction in dendritic spine density in brain-specific profilin1 mutant mice is associated with behavioral deficits.Frontiers in molecular neuroscience · 2022Article
- Ultrasonic Vocalizations in Adult C57BL/6J Mice: The Role of Sex Differences and Repeated Testing.Frontiers in behavioral neuroscience · 2022Article
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Authors and funding
5 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Ultrasonic vocalizations (USVs) are used as a phenotypic marker in mouse models of neuropsychiatric disorders. Nevertheless, current methodologies still require time-consuming manual input or sound recordings clean of any background noise. We developed a method to overcome these two restraints to boost knowledge on mouse USVs. The methods are freely available and the USV analysis runs online at https://usv.pasteur.cloud. As little is currently known about usage and structure of ultrasonic vocalizations during social interactions over the long-term and in unconstrained context, we investigated mouse spontaneous communication by coupling the analysis of USVs with automatic labeling of behaviors. We continuously recorded during 3 days undisturbed interactions of same-sex pairs of C57BL/6J sexually naive males and females at 5 weeks and 3 and 7 months of age. In same-sex interactions, we observed robust differences between males and females in the amount of USVs produced, in the acoustic structure and in the contexts of emission. The context-specific acoustic variations emerged with increasing age. The emission of USVs also reflected a high level of excitement during social interactions. We finally highlighted the importance of studying long-term spontaneous communication by investigating female mice lacking
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