Evidence map›Paper›PMID 34720860›Full record

ReviewFrontiers in neuroscience2021

Oxidative Stress and Cognitive Decline: The Neuroprotective Role of Natural Antioxidants.

Ferdinando Franzoni, Giorgia Scarfò, Sara Guidotti, Jonathan Fusi, Muzaffar Asomov, Carlo Pruneti

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.

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  16. Therapeutic potential ofFrontiers in behavioral neuroscience · 2026
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ferdinando FranzoniDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Giorgia ScarfòDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Sara GuidottiDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Jonathan FusiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Muzaffar AsomovDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Carlo PrunetiDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
University of Pisa · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Free- radicals (Oxygen and Nitrogen species) are formed in mitochondria during the oxidative phosphorylation. Their high reactivity, due to not-engaged electrons, leads to an increase of the oxidative stress. This condition affects above all the brain, that usually needs a large oxygen amount and in which there is the major possibility to accumulate "Reacting Species." Antioxidant molecules are fundamental in limiting free-radical damage, in particular in the central nervous system: the oxidative stress, in fact, seems to worsen the course of neurodegenerative diseases. The aim of this review is to sum up natural antioxidant molecules with the greatest neuroprotective properties against free radical genesis, understanding their relationship with the Central Nervous System.

Indexed as

cognitive declinenatural antioxidantsneurodegenerative diseasesneuroprotectionoxidative stress

Identifiers

PMID34720860
PMCPMC8548611
OpenAlexW3206217851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.