Evidence map›Paper›PMID 34720857›Full record

ArticleFrontiers in neuroscience2021

Structural Differences Across Multiple Visual Cortical Regions in the Absence of Cone Function in Congenital Achromatopsia.

Rebecca Lowndes, Barbara Molz, Lucy Warriner, Anne Herbik, Pieter B de Best, Noa Raz, Andre Gouws, Khazar Ahmadi, Rebecca J McLean, Irene Gottlob and 11 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Mesoscale developmental rivalry in human extrastriate visual cortex.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 4 countries.

Rebecca LowndesDepartment of Psychology, University of York, York, United Kingdom.
Barbara MolzDepartment of Psychology, University of York, York, United Kingdom.
Lucy WarrinerDepartment of Psychology, University of York, York, United Kingdom.
Anne HerbikDepartment of Ophthalmology, University Hospital, Otto von Guericke University, Magdeburg, Germany.
Pieter B de BestMRI Unit, Department of Neurology, Hadassah Medical Center, Jerusalem, Israel.
Noa RazMRI Unit, Department of Neurology, Hadassah Medical Center, Jerusalem, Israel.
Andre GouwsYork Neuroimaging Centre, Department of Psychology, University of York, York, United Kingdom.
Khazar AhmadiDepartment of Ophthalmology, University Hospital, Otto von Guericke University, Magdeburg, Germany.
Rebecca J McLeanUniversity of Leicester Ulverscroft Eye Unit, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom.
Irene GottlobUniversity of Leicester Ulverscroft Eye Unit, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom.
Susanne KohlMolecular Genetics Laboratory, Institute for Ophthalmic Research, Centre for Ophthalmology, University Clinics Tübingen, Tübingen, Germany.
Lars ChoritzDepartment of Ophthalmology, University Hospital, Otto von Guericke University, Magdeburg, Germany.
John MaguireSchool of Optometry and Vision Sciences, University of Bradford, Bradford, United Kingdom.
Martin KanowskiDepartment of Neurology, University Hospital, Otto von Guericke University, Magdeburg, Germany.
Barbara Käsmann-KellnerDepartment of Ophthalmology, Saarland University Hospital and Medical Faculty of the Saarland University Hospital, Homburg, Germany.
Ilse WielandDepartment of Molecular Genetics, Institute for Human Genetics, University Hospital, Otto von Guericke University, Magdeburg, Germany.
Eyal BaninDegenerative Diseases of the Retina Unit, Department of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel.
Netta LevinMRI Unit, Department of Neurology, Hadassah Medical Center, Jerusalem, Israel.
Michael B HoffmannDepartment of Ophthalmology, University Hospital, Otto von Guericke University, Magdeburg, Germany.
Antony B MorlandDepartment of Psychology, University of York, York, United Kingdom.
Heidi A BaselerDepartment of Psychology, University of York, York, United Kingdom.
Otto-von-Guericke University Magdeburg · DEHadassah Medical Center · ILUniversity of York · GBHull York Medical School · GBLeicester Royal Infirmary · GBMax Planck Institute for Psycholinguistics · NLSaarland University · DESTZ eyetrial · DEUniversity of Bradford · GBUniversity of Leicester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most individuals with congenital achromatopsia (ACHM) carry mutations that affect the retinal phototransduction pathway of cone photoreceptors, fundamental to both high acuity vision and colour perception. As the central fovea is occupied solely by cones, achromats have an absence of retinal input to the visual cortex and a small central area of blindness. Additionally, those with complete ACHM have no colour perception, and colour processing regions of the ventral cortex also lack typical chromatic signals from the cones. This study examined the cortical morphology (grey matter volume, cortical thickness, and cortical surface area) of multiple visual cortical regions in ACHM (

Indexed as

achromatopsiaanatomical brain regionscongenital visual impairmentparallel visual pathwaysstructural plasticityventral and dorsal pathwaysvisual areas

Identifiers

PMID34720857
PMCPMC8551799
OpenAlexW3205529853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.