ArticleTobacco induced diseases2021
Electronic cigarette use and its association with asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome among never cigarette smokers.
Article in Tobacco induced diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Guideline
- Association between current e-cigarette use and chronic obstructive pulmonary disease: a meta-analysis focusing on exclusive e-cigarette users.Frontiers in public health · 2026Pooled it
- Association of electronic cigarette use and risk of COPD: a systematic review and meta-analysis.NPJ primary care respiratory medicine · 2025Pooled it
- Population-Based Disease Odds for E-Cigarettes and Dual Use versus Cigarettes.NEJM evidence · 2024Pooled it
- Comparison of e-Cigarette and Cigarette Use and Dual Use Associations With Disease: Updated Systematic Review and Meta-Analysis.Public health reports (Washington, D.C. : 1974)Pooled it
- Human Primary Mesenchymal Stem Cells Fail to Recover Full Osteogenic Differentiation Potential Following Washout of Electronic Cigarette Aerosol Extracts.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Toxicity and Appeal of Flavoured E-Cigarettes and Flavour Ban Outcomes: A Narrative Review.International journal of environmental research and public health · 2026Review
- Inaccurate and misleading meta-analysis of E-cigarettes and population-based diseases.Internal and emergency medicine · 2025Article
- Beyond Smoking: Emerging Drivers of COPD and Their Clinical Implications in Low- and Middle-Income Countries: A Narrative Review.Journal of clinical medicine · 2025Review
- Research - Investigating Biomarkers Linking Tobacco Use with Cadiovascular Disease Occurrence.jLPHA : the official journal of the Louisiana Public Health Association · 2025Article
- The school community's role in addressing vaping: Findings from qualitative research to inform pedagogy, practice and policy.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2025Article
- Dual Use of Electronic Cigarettes and Cigarettes Elevates Risk of Chronic Obstructive Pulmonary Disease and Mental Health Issues: Insights from a Korean Health Survey.International journal of chronic obstructive pulmonary disease · 2025Article
- Association Between E-cigarette Use and Asthma Exacerbations Using Nationally Representative Survey Data.Cureus · 2024Article
- Impact of electronic cigarettes (e-cigs) and heat-not-burn/heated tobacco products (HnB/HTP) on asthma and chronic obstructive pulmonary disease: a viewpoint of the Italian Society of Internal Medicine.Internal and emergency medicine · 2024Review
- Vaping habits and respiratory symptoms using a smartphone app platform.BMC public health · 2024Article
- Impact of electronic cigarette usage on the onset of respiratory symptoms and COPD among Chinese adults.Scientific reports · 2024Article
- Respiratory chronic health conditions and racial disparities associated with e-cigarette use: a cross-sectional analysis using behavioral risk factor surveillance data.Frontiers in public health · 2024Article
- A Review of Toxicity Mechanism Studies of Electronic Cigarettes on Respiratory System.International journal of molecular sciences · 2022Review
- Acute Outcomes of Cigarette Smoke and Electronic Cigarette Aerosol Inhalation in a Murine Model.BioMed research international · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlthough smoking is a strong risk factor for lung diseases including asthma, COPD, and asthma-COPD overlap syndrome (ACOS), studies are needed to examine the association between e-cigarettes and asthma, COPD, and ACOS. This study evaluated the association between e-cigarette use and self-reported diagnosis of asthma, COPD, and ACOS using a large nationally representative sample of adults aged ≥18 years in the United States.
methodsCross-sectional data from the Behavioral Risk Factor Surveillance System (BRFSS) from 2016 to 2018 were used to examine self-reported information on current e-cigarette use, demographic variables, and asthma and COPD status among never cigarette smokers (n=8736). Asthma and COPD were measured by self-reported diagnosis, and respondents who reported having both diagnoses were then classified as having ACOS. Of the 469077 never cigarette smokers, 4368 non-e-cigarette users were 1:1 propensity score-matched to e-cigarette users on age, sex, race/ethnicity and education level. We used multinomial logistic regression to examine association between current e-cigarette use and self-report asthma, COPD, and ACOS while controlling for marital status and employment in addition to matching variables.
resultsCompared with never e-cigarette users, e-cigarette users had increased odds of self-reported ACOS (OR=2.27; 95% CI: 2.23-2.31), asthma (OR=1.26; 95% CI: 1.25-1.27) and COPD (OR=1.44; 95% CI: 1.42-1.46).
conclusionsOur findings suggest that e-cigarette use is associated with an increased odds of self-reported asthma, COPD, and ACOS among never combustible cigarette smokers. BRFSS provides cross-sectional survey data, therefore a causal relationship between e-cigarette use and the three lung diseases cannot be evaluated. Future longitudinal studies are needed to validate these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.