Evidence map›Paper›PMID 34720664›Full record

ArticleSarcoma2021

The Influence of Personalised Sarcoma Care (PERSARC) Prediction Modelling on Clinical Decision Making in a Multidisciplinary Setting.

H S Femke Hagenmaier, Annelies G K van Beeck, Rick L Haas, Veroniek M van Praag, Leti van Bodegom-Vos, Jos A van der Hage, Stijn Krol, Frank M Speetjens, Arjen H G Cleven, Ana Navas and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Sarcoma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

H S Femke HagenmaierDepartment of Orthopaedic Surgery, Sint Maartenskliniek, Hengstdal 3, 6574 NA Ubbergen, Netherlands.ORCID https://orcid.org/0000-0001-6744-6021
Annelies G K van BeeckDepartment of Orthopaedic Surgery, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, Netherlands.
Rick L HaasDepartment of Radiotherapy, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, Netherlands.ORCID https://orcid.org/0000-0003-4834-4331
Veroniek M van PraagDepartment of Orthopaedic Surgery, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, Netherlands.
Leti van Bodegom-VosDepartment of Biomedical Data Sciences, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, Netherlands.
Jos A van der HageDepartment of Surgery, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, Netherlands.
Stijn KrolDepartment of Radiotherapy, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, Netherlands.
Frank M SpeetjensDepartment of Clinical Oncology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, Netherlands.
Arjen H G ClevenDepartment of Pathology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, Netherlands.
Ana NavasDepartment of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, Netherlands.
Herman M KroonDepartment of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, Netherlands.
Rieneke G Moeri-SchimmelDepartment of Radiotherapy, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, Netherlands.
Nicolette A C LeyerzapfDepartment of Orthopaedic Surgery, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, Netherlands.
Michiel A J van de SandeDepartment of Orthopaedic Surgery, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, Netherlands.ORCID https://orcid.org/0000-0002-9156-7656
Leiden University · NLSint Maartenskliniek · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith soft-tissue sarcoma of the extremity (ESTS) representing a heterogenous group of tumors, management decisions are often made in multidisciplinary team (MDT) meetings. To optimize outcome, nomograms are more commonly used to guide individualized treatment decision making. PURPOSE: To evaluate the influence of Personalised Sarcoma Care (PERSARC) on treatment decisions for patients with high-grade ESTS and the ability of the MDT to accurately predict overall survival (OS) and local recurrence (LR) rates.

methodsTwo consecutive meetings were organised. During the first meeting, 36 cases were presented to the MDT. OS and LR rates without the use of PERSARC were estimated by consensus and preferred treatment was recorded for each case. During the second meeting, OS/LR rates calculated with PERSARC were presented to the MDT. Differences between estimated OS/LR rates and PERSARC OS/LR rates were calculated. Variations in preferred treatment protocols were noted.

resultsThe MDT underestimated OS when compared to PERSARC in 48.4% of cases. LR rates were overestimated in 41.9% of cases. With the use of PERSARC, the proposed treatment changed for 24 cases.

conclusionPERSARC aids the MDT to optimize individualized predicted OS and LR rates, hereby guiding patient-centered care and shared decision making.

Identifiers

PMID34720664
PMCPMC8553471
OpenAlexW3207527665

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.